Anti-MATN3 Antibody (CAB7700)
- SKU:
- CAB7700
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-MATN3 Antibody |
| Antibody SKU: | CAB7700 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 277-486 of human MATN3 (NP_002372.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse brain, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 277-486 of human MATN3 (NP_002372.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HVCI SDGE GKHH CECS QGYT LNAD KKTC SALD RCAL NTHG CEHI CVND RSGS YHCE CYEG YTLN EDRK TCSA QDKC ALGT HGCQ HICV NDRT GSHH CECY EGYT LNAD KKTC SVRD KCAL GSHG CQHI CVSD GAAS YHCD CYPG YTLN EDKK TCSA TEEA RRLV STED ACGC EATL AFQD KVSS YLQR LNTK LDDI LEKL KINE YGQI HR |
| Gene ID: | 4148 |
| Uniprot: | O15232 |
| Cellular Location: | Secreted |
| Calculated MW: | 48kDa/52kDa |
| Observed MW: | 53kDa |
| Synonyms: | MATN3, DIPOA, EDM5, HOA, OADIP, OS2 |
| Background: | This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains two von Willebrand factor A domains; it is present in the cartilage extracellular matrix and has a role in the development and homeostasis of cartilage and bone. Mutations in this gene result in multiple epiphyseal dysplasia. |
| UniProt Protein Function: | MATN3: Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. Defects in MATN3 are the cause of multiple epiphyseal dysplasia type 5 (EDM5). EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types. EDM5 is relatively mild and clinically variable. It is primarily characterized by delayed and irregular ossification of the epiphyses and early-onset osteoarthritis. Defects in MATN3 are the cause of spondyloepimetaphyseal dysplasia MATN3-related (SEMD-MATN3). A bone disease characterized by disproportionate early-onset dwarfism, bowing of the lower limbs, lumbar lordosis and normal hands. Skeletal abnormalities include short, wide and stocky long bones with severe epiphyseal and metaphyseal changes, hypoplastic iliac bones and flat, ovoid vertebral bodies. Genetic variations in MATN3 are associated with susceptibility to osteoarthritis type 2 (OS2); also called osteoarthritis of distal interphalangeal joints (OADIP) or hand osteoarthritis (HOA). Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. In the hand, osteoarthritis can develop in the distal interphalangeal and the first carpometacarpal (base of thumb) and proximal interphalangeal joints. Patients with osteoarthritis may have one, a few, or all of these sites affected. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2p24-p23 Cellular Component: proteinaceous extracellular matrix; extracellular region Molecular Function:protein binding; extracellular matrix structural constituent Biological Process: extracellular matrix organization and biogenesis; skeletal development Disease: Osteoarthritis Susceptibility 2; Spondyloepimetaphyseal Dysplasia, Matrilin-3 Related; Epiphyseal Dysplasia, Multiple, 5 |
| NCBI Summary: | This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains two von Willebrand factor A domains; it is present in the cartilage extracellular matrix and has a role in the development and homeostasis of cartilage and bone. Mutations in this gene result in multiple epiphyseal dysplasia. [provided by RefSeq] |
| UniProt Code: | O15232 |
| NCBI GenInfo Identifier: | 11321565 |
| NCBI Gene ID: | 4148 |
| NCBI Accession: | NP_002372.1 |
| UniProt Secondary Accession: | O15232,Q4ZG02, |
| UniProt Related Accession: | O15232 |
| Molecular Weight: | 52,817 Da |
| NCBI Full Name: | matrilin-3 |
| NCBI Synonym Full Names: | matrilin 3 |
| NCBI Official Symbol: | MATN3 |
| NCBI Official Synonym Symbols: | HOA; OS2; EDM5; DIPOA; OADIP |
| NCBI Protein Information: | matrilin-3; OTTHUMP00000200547 |
| UniProt Protein Name: | Matrilin-3 |
| Protein Family: | Matrilin |
| UniProt Gene Name: | MATN3 |
| UniProt Entry Name: | MATN3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MATN3 antibody (CAB7700) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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