Anti-MAT2B Antibody (CAB11608)
- SKU:
- CAB11608
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-MAT2B Antibody |
| Antibody SKU: | CAB11608 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human MAT2B (NP_037415.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Mouse brain, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human MAT2B (NP_037415.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVGR EKEL SIHF VPGS CRLV EEEV NIPN RRVL VTGA TGLL GRAV HKEF QQNN WHAV GCGF RRAR PKFE QVNL LDSN AVHH IIHD FQPH VIVH CAAE RRPD VVEN QPDA ASQL NVDA SGNL AKEA AAVG AFLI YISS DYVF DGTN PPYR EEDI PAPL NLYG KTKL DGEK AVLE NNLG AAVL RIPI LYGE VEKL EESA VTVM FDKV QFSN KSAN MDHW QQRF PTHV KDVA TVCR QLAE KRML DPSI KGTF HWSG NEQM TKYE MACA IADA FNLP SSHL RPIT DSPV LGAQ RPRN AQLD CSKL ETLG IGQR TPFR IGIK ESLW PFLI DKRW RQTV FH |
| Gene ID: | 27430 |
| Uniprot: | Q9NZL9 |
| Cellular Location: | |
| Calculated MW: | 9kDa/28kDa/34kDa/36kDa/37kDa |
| Observed MW: | 37kDa |
| Synonyms: | MAT2B, MAT-II, MATIIbeta, Nbla02999, SDR23E1, TGR |
| Background: | The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | MAT2B: Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S- adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S- adenosylmethionine inhibition. Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transferase; Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - cysteine and methionine Chromosomal Location of Human Ortholog: 5q34 Cellular Component: methionine adenosyltransferase complex; mitochondrion; intracellular; cytosol; nucleus Molecular Function:enzyme binding; methionine adenosyltransferase regulator activity Biological Process: methylation; regulation of catalytic activity; xenobiotic metabolic process; S-adenosylmethionine biosynthetic process; one-carbon compound metabolic process |
| NCBI Summary: | The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012] |
| UniProt Code: | Q9NZL9 |
| NCBI GenInfo Identifier: | 74719662 |
| NCBI Gene ID: | 27430 |
| NCBI Accession: | Q9NZL9.1 |
| UniProt Secondary Accession: | Q9NZL9,Q1WAI7, Q27J92, Q3LIE8, Q567T7, Q6NYC7, Q9BS89 Q9H3E1, Q9UJ54, B2R5Y6, |
| UniProt Related Accession: | Q9NZL9 |
| Molecular Weight: | 334 |
| NCBI Full Name: | Methionine adenosyltransferase 2 subunit beta |
| NCBI Synonym Full Names: | methionine adenosyltransferase II, beta |
| NCBI Official Symbol: | MAT2B |
| NCBI Official Synonym Symbols: | TGR; MAT-II; SDR23E1; MATIIbeta; Nbla02999 |
| NCBI Protein Information: | methionine adenosyltransferase 2 subunit beta; MAT II beta; putative protein product of Nbla02999; dTDP-4-keto-6-deoxy-D-glucose 4-reductase; putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase; short chain dehydrogenase/reductase family 23E, member 1; bet |
| UniProt Protein Name: | Methionine adenosyltransferase 2 subunit beta |
| UniProt Synonym Protein Names: | Methionine adenosyltransferase II beta; MAT II beta; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase |
| Protein Family: | Methionine adenosyltransferase |
| UniProt Gene Name: | MAT2B |
| UniProt Entry Name: | MAT2B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MAT2B antibody (CAB11608) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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