Anti-MAP3K14 Antibody (CAB11585)
- SKU:
- CAB11585
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-MAP3K14 Antibody |
| Antibody SKU: | CAB11585 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 648-947 of human MAP3K14 (NP_003945.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 648-947 of human MAP3K14 (NP_003945.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GGKV NRAL QQVG GLKS PWRG EYKE PRHP PPNQ ANYH QTLH AQPR ELSP RAPG PRPA EETT GRAP KLQP PLPP EPPE PNKS PPLT LSKE ESGM WEPL PLSS LEPA PARN PSSP ERKA TVPE QELQ QLEI ELFL NSLS QPFS LEEQ EQIL SCLS IDSL SLSD DSEK NPSK ASQS SRDT LSSG VHSW SSQA EARS SSWN MVLA RGRP TDTP SYFN GVKV QIQS LNGE HLHI REFH RVKV GDIA TGIS SQIP AAAF SLVT KDGQ PVRY DMEV PDSG IDLQ CTLA PDGS FAWS WRVK HGQL ENRP |
| Gene ID: | 9020 |
| Uniprot: | Q99558 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 104kDa |
| Observed MW: | 104kDa |
| Synonyms: | MAP3K14, FTDCR1B, HS, HSNIK, NIK |
| Background: | This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. |
| UniProt Protein Function: | Nik: a protein kinase of the STE group of kinases. Binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. |
| UniProt Protein Details: | Protein type:EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE-Unique family Chromosomal Location of Human Ortholog: 17q21.31 Cellular Component: cytoplasm; cytosol; fibrillar center; intracellular membrane-bound organelle; nucleus Molecular Function:kinase activity; NF-kappaB-inducing kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity Biological Process: actin cytoskeleton organization and biogenesis; I-kappaB kinase/NF-kappaB cascade; immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; T cell costimulation; tumor necrosis factor-mediated signaling pathway |
| NCBI Summary: | This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99558 |
| NCBI GenInfo Identifier: | 92090612 |
| NCBI Gene ID: | 9020 |
| NCBI Accession: | Q99558.2 |
| UniProt Secondary Accession: | Q99558,Q8IYN1, A8K2D8, D3DX67, |
| UniProt Related Accession: | Q99558 |
| Molecular Weight: | 104kDa |
| NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 14 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 14 |
| NCBI Official Symbol: | MAP3K14 |
| NCBI Official Synonym Symbols: | HS; NIK; HSNIK; FTDCR1B |
| NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 14 |
| UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 14 |
| UniProt Synonym Protein Names: | NF-kappa-beta-inducing kinase; HsNIK; Serine/threonine-protein kinase NIK |
| Protein Family: | Mitogen-activated protein kinase kinase kinase |
| UniProt Gene Name: | MAP3K14 |
 | Western blot analysis of extracts of Raji cells, using MAP3K14 antibody (CAB11585) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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