| Synonyms: | MAP2K7, JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4, MEK7, MKK7 |
| Background: | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | MKK7: a dual-specificity protein kinase of the STE7 family. Activates JNK1 and -2 by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by proinflammatory cytokines and environmental stress. Three alternatively spliced isoforms have been reported. |
| UniProt Protein Details: | Protein type:Protein kinase, dual-specificity (non-receptor); EC 2.7.12.2; Protein kinase, STE; Kinase, protein; STE group; STE7 family Chromosomal Location of Human Ortholog: 19p13.3-p13.2 Cellular Component: cytoplasm; intracellular; nucleus; cytosol Molecular Function:MAP kinase kinase activity; protein C-terminus binding; protein serine/threonine kinase activity; protein binding; enzyme binding; protein-tyrosine kinase activity; magnesium ion binding; mitogen-activated protein kinase kinase kinase binding; JUN kinase kinase activity; protein kinase binding; protein phosphatase binding; ATP binding Biological Process: peptidyl-tyrosine phosphorylation; apoptosis; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; pathogenesis; toll-like receptor 3 signaling pathway; signal transduction; response to osmotic stress; activation of JNK activity; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; response to heat; positive regulation of neuron apoptosis; toll-like receptor signaling pathway; innate immune response; JNK cascade; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway; response to UV |
| NCBI Summary: | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | O14733 |
| NCBI GenInfo Identifier: | 6831583 |
| NCBI Gene ID: | 5609 |
| NCBI Accession: | O14733.2 |
| UniProt Secondary Accession: | O14733,O14648, O14816, O60452, O60453, Q1PG43, Q8IY10 B2R9S5, D6W659, |
| UniProt Related Accession: | O14733 |
| Molecular Weight: | 419 |
| NCBI Full Name: | Dual specificity mitogen-activated protein kinase kinase 7 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase 7 |
| NCBI Official Symbol: | MAP2K7 |
| NCBI Official Synonym Symbols: | MEK; MKK7; JNKK2; MEK 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4 |
| NCBI Protein Information: | dual specificity mitogen-activated protein kinase kinase 7; SAPK kinase 4; MAPK/ERK kinase 7; MAP kinase kinase 7; JNK-activating kinase 2; c-Jun N-terminal kinase kinase 2; stress-activated protein kinase kinase 4 |
| UniProt Protein Name: | Dual specificity mitogen-activated protein kinase kinase 7 |
| UniProt Synonym Protein Names: | JNK-activating kinase 2; MAPK/ERK kinase 7; MEK 7; Stress-activated protein kinase kinase 4; SAPK kinase 4; SAPKK-4; SAPKK4; c-Jun N-terminal kinase kinase 2; JNK kinase 2; JNKK 2 |
| Protein Family: | Dual specificity mitogen-activated protein kinase kinase |
| UniProt Gene Name: | MAP2K7 |
| UniProt Entry Name: | MP2K7_HUMAN |
