Anti-MAOB 항체 (CAB1568)

Antibody Name:	Anti-MAOB Antibody
Antibody SKU:	CAB1568
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MAOB (NP_000889.3).

Application:	WB IHC IF
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MAOB (NP_000889.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MSNK CDVV VVGG GISG MAAA KLLH DSGL NVVV LEAR DRVG GRTY TLRN QKVK YVDL GGSY VGPT QNRI LRLA KELG LETY KVNE VERL IHHV KGKS YPFR GPFP PVWN PITY LDHN NFWR TMDD MGRE IPSD APWK APLA EEWD NMTM KELL DKLC WTES AKQL ATLF VNLC VTAE THEV SALW FLWY VKQC GGTT RIIS TTNG GQER KFVG GSGQ VSER IMDL LGDR VKLE RPVI YIDQ TREN VLVE TLNH EMYE AKYV
Gene ID:	4129
Uniprot:	P27338
Cellular Location:	Cytoplasmic side, Mitochondrion outer membrane, Single-pass type IV membrane protein
Calculated MW:	46kDa/58kDa
Observed MW:	60KDa

Synonyms:

MAOB

Background:

The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine.

UniProt Protein Function:	MAOB: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. Belongs to the flavin monoamine oxidase family.
UniProt Protein Details:	Protein type:Mitochondrial; Amino Acid Metabolism - arginine and proline; EC 1.4.3.4; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - histidine; Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tryptophan Chromosomal Location of Human Ortholog: Xp11.23 Cellular Component: mitochondrial envelope; mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; integral to membrane Molecular Function:amine oxidase activity; protein homodimerization activity; electron carrier activity; FAD binding Biological Process: response to drug; negative regulation of serotonin secretion; positive regulation of dopamine metabolic process; response to selenium ion; response to ethanol; substantia nigra development; dopamine catabolic process; response to toxin; xenobiotic metabolic process; response to lipopolysaccharide; hydrogen peroxide biosynthetic process; response to corticosterone stimulus; response to aluminum ion
NCBI Summary:	The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]
UniProt Code:	P27338
NCBI GenInfo Identifier:	113980
NCBI Gene ID:	4129
NCBI Accession:	P27338.3
UniProt Secondary Accession:	P27338,Q7Z6S2, B2R6R3, B7Z5H3, D3DWC3,
UniProt Related Accession:	P27338
Molecular Weight:	520
NCBI Full Name:	Amine oxidase
NCBI Synonym Full Names:	monoamine oxidase B
NCBI Official Symbol:	MAOB
NCBI Protein Information:	amine oxidase [flavin-containing] B; amine oxidase [flavin-containing] B; MAO-B; MAO, brain; MAO, platelet; tyramine oxidase; adrenalin oxidase; monoamine oxidase type B
UniProt Protein Name:	Amine oxidase [flavin-containing] B
UniProt Synonym Protein Names:	Monoamine oxidase type B; MAO-B
Protein Family:	Amine oxidase
UniProt Gene Name:	MAOB
UniProt Entry Name:	AOFB_HUMAN

	Western blot analysis of extracts of HeLa cells, using MAOB antibody (CAB1568) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
	Immunohistochemistry of paraffin-embedded human colon using MAOB Rabbit pAb (CAB1568) at dilution of 100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse lung using MAOB Rabbit pAb (CAB1568) at dilution of 100 (40x lens).
	Immunohistochemistry of paraffin-embedded rat lung using MAOB Rabbit pAb (CAB1568) at dilution of 100 (40x lens).
	Immunofluorescence analysis of L929 cells using MAOB Rabbit pAb (CAB1568) at dilution of 1:100. Blue: DAPI for nuclear staining.

Antibodies	ELISA Kits
Anti-Monoamine Oxidase B Antibody (CAB11597)	Human MAOB / Monoamine Oxidase B ELISA Kit
MAOB Antibody (PACO10357)	Human Amine oxidase [flavin-containing] B (MAOB) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)