Anti-MAD3/MXD3 Antibody (CAB19807)

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SKU:
CAB19807
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
BHLHC13
MAD3
MYX
Frequently bought together:

Description

Product Name:MAD3/MXD3 Rabbit mAb
Product Code:CAB19807
Size:20uL, 50uL, 100uL
Synonyms:BHLHC13, MAD3, MYX
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human MAD3/MXD3
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, DU145, Jurkat
Immunogen:A synthesized peptide derived from human MAD3/MXD3
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:83463
Uniprot:Q9BW11
Calculated MW:28kDa
Observed MW:24KDa
UniProt Protein Function:MXD3: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 5q35.3

Molecular Function:protein binding

NCBI Summary:This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
UniProt Code:Q9BW11
NCBI GenInfo Identifier:74733390
NCBI Gene ID:83463
NCBI Accession:Q9BW11.1
UniProt Secondary Accession:Q9BW11,Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3, B4E0J1,
UniProt Related Accession:Q9BW11
Molecular Weight:42,821 Da
NCBI Full Name:Max dimerization protein 3
NCBI Synonym Full Names:MAX dimerization protein 3
NCBI Official Symbol:MXD3  
NCBI Official Synonym Symbols:MYX; MAD3; BHLHC13  
NCBI Protein Information:max dimerization protein 3
UniProt Protein Name:Max dimerization protein 3
UniProt Synonym Protein Names:Class C basic helix-loop-helix protein 13; bHLHc13; Max-associated protein 3; Max-interacting transcriptional repressor MAD3; Myx
Protein Family:Max dimerization protein
UniProt Gene Name:MXD3  
UniProt Entry Name:MAD3_HUMAN

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