Anti-M6PR Antibody (CAB19907)[KO Validated]

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SKU:
CAB19907
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
Frequently bought together:

Description

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Antibody Name:Anti-M6PR Antibody [KO Validated]
Antibody SKU:CAB19907
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human M6PR.
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T
Immunogen:Recombinant protein of human M6PR.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4074
Uniprot:P20645
Cellular Location:Lysosome membrane, Single-pass type I membrane protein
Calculated MW:30kDa
Observed MW:31KDa
Anti-M6PR Antibody [KO Validated] (CAB19907)Western blot analysis of extracts from normal (control) and M6PR knockout (KO) 293T cells, using M6PR antibody (CAB19907) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Synonyms:M6PR, CD-M6PR, CD-MPR, MPR 46, MPR-46, MPR46, SMPR
Background:This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.
UniProt Protein Function:M6PR: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: endosome; integral to plasma membrane; membrane; perinuclear region of cytoplasm; trans-Golgi network; trans-Golgi network membrane; transport vesicle

Molecular Function:transmembrane receptor activity

Biological Process: endosome to lysosome transport; receptor-mediated endocytosis

NCBI Summary:This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
UniProt Code:P20645
NCBI GenInfo Identifier:127293
NCBI Gene ID:4074
NCBI Accession:P20645.1
UniProt Secondary Accession:P20645,A8K528, D3DUV5,
UniProt Related Accession:P20645
Molecular Weight:30,993 Da
NCBI Full Name:Cation-dependent mannose-6-phosphate receptor
NCBI Synonym Full Names:mannose-6-phosphate receptor, cation dependent
NCBI Official Symbol:M6PR  
NCBI Official Synonym Symbols:SMPR; MPR46; CD-MPR; MPR 46; MPR-46; CD-M6PR  
NCBI Protein Information:cation-dependent mannose-6-phosphate receptor
UniProt Protein Name:Cation-dependent mannose-6-phosphate receptor
UniProt Synonym Protein Names:46 kDa mannose 6-phosphate receptor; MPR 46
Protein Family:Cation-dependent mannose-6-phosphate receptor
UniProt Gene Name:M6PR  
UniProt Entry Name:MPRD_HUMAN

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