Anti-LYZ Antibody (CAB13511)
- SKU:
- CAB13511
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
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Description
| Antibody Name: | Anti-LYZ Antibody |
| Antibody SKU: | CAB13511 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LYZ (NP_000230.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HL-60, U-937, Mouse lung |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LYZ (NP_000230.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKAL IVLG LVLL SVTV QGKV FERC ELAR TLKR LGMD GYRG ISLA NWMC LAKW ESGY NTRA TNYN AGDR STDY GIFQ INSR YWCN DGKT PGAV NACH LSCS |
| Gene ID: | 4069 |
| Uniprot: | P61626 |
| Cellular Location: | Secreted |
| Calculated MW: | 16kDa |
| Observed MW: | 13kDa |
| Synonyms: | LYZ, LYZF1, LZM, lysozyme |
| Background: | This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. |
| UniProt Protein Function: | LYZ: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents. Defects in LYZ are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Belongs to the glycosyl hydrolase 22 family. |
| UniProt Protein Details: | Protein type:EC 3.2.1.17; Endoplasmic reticulum; Secreted, signal peptide; Vesicle; Secreted; Hydrolase Chromosomal Location of Human Ortholog: 12q15 Cellular Component: extracellular space; extracellular region Molecular Function:identical protein binding; lysozyme activity Biological Process: retinal homeostasis; metabolic process; cytolysis; defense response to bacterium; inflammatory response Disease: Amyloidosis, Familial Visceral |
| NCBI Summary: | This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014] |
| UniProt Code: | P61626 |
| NCBI GenInfo Identifier: | 48428995 |
| NCBI Gene ID: | 4069 |
| NCBI Accession: | P61626.1 |
| UniProt Related Accession: | P61626 |
| Molecular Weight: | ~ 17kDa |
| NCBI Full Name: | Lysozyme C |
| NCBI Synonym Full Names: | lysozyme |
| NCBI Official Symbol: | LYZ |
| NCBI Official Synonym Symbols: | LZM; LYZF1 |
| NCBI Protein Information: | lysozyme C |
| UniProt Protein Name: | Lysozyme C |
| UniProt Synonym Protein Names: | 1,4-beta-N-acetylmuramidase C |
| UniProt Gene Name: | LYZ |
| UniProt Entry Name: | LYSC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LYZ antibody (CAB13511) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using LYZ antibody (CAB13511) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using LYZ antibody (CAB13511) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using LYZ antibody (CAB13511) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using LYZ antibody (CAB13511) at dilution of 1:100 (40x lens). |
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