Anti-LYPLA1 Antibody (CAB4419)
- SKU:
- CAB4419
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- LYPLA1
- APT-1
- APT1
- LPL-I
- LPL1
- hAPT1
Frequently bought together:
Description
| Product Name: | LYPLA1 Rabbit pAb |
| Product Code: | CAB4419 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | LYPLA1, APT-1, APT1, LPL-I, LPL1, hAPT1 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human LYPLA1 (NP_006321.1). |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | LO2, Mouse heart, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human LYPLA1 (NP_006321.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MCGN NMST PLPA IVPA ARKA TAAV IFLH GLGD TGHG WAEA FAGI RSSH IKYI CPHA PVRP VTLN MNVA MPSW FDII GLSP DSQE DESG IKQA AENI KALI DQEV KNGI PSNR IILG GFSQ GGAL SLYT ALTT QQKL AGVT ALSC WLPL RASF PQGP IGGA NRDI SILQ CHGD CDPL VPLM FGSL TVEK LKTL VNPA NVTF KTYE GMMH SSCQ QEMM DVKQ FIDK LLPP ID |
| Gene ID: | 10434 |
| Uniprot: | O75608 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 22kDa/24kDa |
| Observed MW: | 25kDa |
| UniProt Protein Function: | LYPLA1: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity. Belongs to the AB hydrolase 2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - glycerophospholipid; Phospholipase; EC 3.1.2.- Chromosomal Location of Human Ortholog: 8q11.23 Cellular Component: cytoplasm; cytosol Molecular Function:lipase activity; lysophospholipase activity; palmitoyl-(protein) hydrolase activity Biological Process: protein depalmitoylation; regulation of nitric-oxide synthase activity |
| NCBI Summary: | This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013] |
| UniProt Code: | O75608 |
| NCBI GenInfo Identifier: | 41017274 |
| NCBI Gene ID: | 10434 |
| NCBI Accession: | O75608.1 |
| UniProt Secondary Accession: | O75608,O43202, Q9UQF9, |
| UniProt Related Accession: | O75608 |
| Molecular Weight: | 22,875 Da |
| NCBI Full Name: | Acyl-protein thioesterase 1 |
| NCBI Synonym Full Names: | lysophospholipase I |
| NCBI Official Symbol: | LYPLA1 |
| NCBI Official Synonym Symbols: | APT1; LPL1; APT-1; LPL-I; hAPT1 |
| NCBI Protein Information: | acyl-protein thioesterase 1 |
| UniProt Protein Name: | Acyl-protein thioesterase 1 |
| UniProt Synonym Protein Names: | Lysophospholipase 1; Lysophospholipase I; LPL-I; LysoPLA I |
| UniProt Gene Name: | LYPLA1 |
| UniProt Entry Name: | LYPA1_HUMAN |
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