Anti-LTC4S Antibody (CAB15071)
- SKU:
- CAB15071
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-LTC4S Antibody |
| Antibody SKU: | CAB15071 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human LTC4S (NP_665874.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-549 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human LTC4S (NP_665874.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YRAQ VNCS EYFP LFLA TLWV AGIF FHEG AAAL CGLV YLFA RLRY FQGY ARSA QLRL APLY ASAR ALWL LVAL AALG LLAH FLPA ALRA ALLG RLRT LLPW A |
| Gene ID: | 4056 |
| Uniprot: | Q16873 |
| Cellular Location: | Endoplasmic reticulum membrane, Multi-pass membrane protein, Nucleus outer membrane |
| Calculated MW: | 16kDa |
| Observed MW: | 17kDa |
| Synonyms: | LTC4S |
| Background: | The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. |
| UniProt Protein Function: | LTC4S: Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency). LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly. Belongs to the MAPEG family. |
| UniProt Protein Details: | Protein type:Lyase; Nuclear envelope; Membrane protein, integral; EC 4.4.1.20; Membrane protein, multi-pass; Lipid Metabolism - arachidonic acid; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 5q35 Cellular Component: endoplasmic reticulum; intracellular membrane-bound organelle; nuclear envelope Molecular Function:glutathione peroxidase activity; glutathione transferase activity; leukotriene-C4 synthase activity; lipid binding; protein binding Biological Process: leukotriene biosynthetic process; leukotriene metabolic process; lipoxygenase pathway Disease: Leukotriene C4 Synthase Deficiency |
| NCBI Summary: | The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16873 |
| NCBI GenInfo Identifier: | 2833283 |
| NCBI Gene ID: | 4056 |
| NCBI Accession: | Q16873.1 |
| UniProt Secondary Accession: | Q16873,Q8N6P0, Q9UC73, Q9UD18, |
| UniProt Related Accession: | Q16873 |
| Molecular Weight: | 16,567 Da |
| NCBI Full Name: | Leukotriene C4 synthase |
| NCBI Synonym Full Names: | leukotriene C4 synthase |
| NCBI Official Symbol: | LTC4S |
| NCBI Protein Information: | leukotriene C4 synthase |
| UniProt Protein Name: | Leukotriene C4 synthase |
| UniProt Synonym Protein Names: | Leukotriene-C(4) synthase |
| Protein Family: | Leukotriene C4 synthase |
| UniProt Gene Name: | LTC4S |
| UniProt Entry Name: | LTC4S_HUMAN |
 | Western blot analysis of extracts of A-549 cells, using LTC4S antibody (CAB15071) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90. |
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