Anti-LSS Antibody (CAB6930)

(No reviews yet) Write a Review
SKU:
CAB6930
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-LSS Antibody
Antibody SKU:CAB6930
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LSS (NP_002331.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:BT-474, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LSS (NP_002331.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTEG TCLR RRGG PYKT EPAT DLGR WRLN CERG RQTW TYLQ DERA GREQ TGLE AYAL GLDT KNYF KDLP KAHT AFEG ALNG MTFY VGLQ AEDG HWTG DYGG PLFL LPGL LITC HVAR IPLP AGYR EEIV RYLR SVQL PDGG WGLH IEDK STVF GTAL NYVS LRIL GVGP DDPD LVRA RNIL HKKG GAVA IPSW GKFW LAVL NVYS WEGL NTLF PEMW LFPD WAPA HPST LWCH CRQV YLPM SYCY AVRL SAAE DPLV QSLR QELY VEDF ASID WLAQ RNNV APDE LYTP HSWL LRVV YALL
Gene ID:4047
Uniprot:P48449
Cellular Location:Endoplasmic reticulum membrane, Peripheral membrane protein
Calculated MW:74kDa/82kDa/83kDa
Observed MW:75kDa
Synonyms:LSS, CTRCT44, OSC
Background:The protein encoded by this gene catalyzes the conversion of (S)-2, 3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:LSS: Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Belongs to the terpene cyclase/mutase family.
UniProt Protein Details:

Protein type:Lipid Metabolism - steroid biosynthesis; EC 5.4.99.7; Isomerase

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: endoplasmic reticulum membrane; membrane; lipid particle

Molecular Function:lanosterol synthase activity

Biological Process: steroid metabolic process; cholesterol biosynthetic process

Disease: Cataract 44

NCBI Summary:The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]
UniProt Code:P48449
NCBI GenInfo Identifier:1352387
NCBI Gene ID:4047
NCBI Accession:P48449.1
UniProt Secondary Accession:P48449,Q8IYL6, Q9UEZ1, B4DJZ9, D3DSN0, E9PEI9, G5E9Q9
UniProt Related Accession:P48449
Molecular Weight:82,199 Da
NCBI Full Name:Lanosterol synthase
NCBI Synonym Full Names:lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
NCBI Official Symbol:LSS  
NCBI Official Synonym Symbols:OSC  
NCBI Protein Information:lanosterol synthase; hOSC; oxidosqualene--lanosterol cyclase; 2,3-epoxysqualene-lanosterol cyclase; 2,3-epoxysqualene--lanosterol cyclase
UniProt Protein Name:Lanosterol synthase
UniProt Synonym Protein Names:2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC; hOSC
Protein Family:Lysostaphin
UniProt Gene Name:LSS  
UniProt Entry Name:ERG7_HUMAN
Anti-LSS Antibody (CAB6930)Western blot analysis of extracts of various cell lines, using LSS antibody (CAB6930) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

0 Reviews

View AllClose

Related Products