Anti-LPIN2 Antibody (CAB15762)
- SKU:
- CAB15762
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-LPIN2 Antibody |
| Antibody SKU: | CAB15762 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-400 of human LPIN2 (NP_055461.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | LO2, 293T, A-549, DU145, Mouse liver, Mouse lung, Mouse kidney, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-400 of human LPIN2 (NP_055461.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TCDV GVSS DDDK GAQA ARGS SNAS LKEE ECKE PLLF HSGD HYPL SDGD WSPL ETTY PQTA CPKS DSEL EVKP AESL LRSE SHME WTWG GFPE STKV SKRE RSDH HPRT ATIT PSEN THFR VIPS EDNL ISEV EKDA SMED TVCT IVKP KPRA LGTQ MSDP TSVA ELLE PPLE STQI SSML DADH LPNA ALAE APSE SKPA AKVD SPSK KKGV HKRS QHQG P |
| Gene ID: | 9663 |
| Uniprot: | Q92539 |
| Cellular Location: | Cytoplasm, Endoplasmic reticulum membrane, Nucleus, cytosol |
| Calculated MW: | 99kDa |
| Observed MW: | 110kDa |
| Synonyms: | LPIN2, lipin 2 |
| Background: | Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. |
| UniProt Protein Function: | LPIN2: Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. Defects in LPIN2 are the cause of Majeed syndrome (MAJEEDS). An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration). Belongs to the lipin family. |
| UniProt Protein Details: | Protein type:EC 3.1.3.4; Phosphatase (non-protein); Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 18p11.31 Cellular Component: cytosol; endoplasmic reticulum membrane; nucleus Molecular Function:phosphatidate phosphatase activity; transcription coactivator activity Biological Process: fatty acid catabolic process; lipid metabolic process; phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; triacylglycerol biosynthetic process Disease: Majeed Syndrome |
| NCBI Summary: | Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92539 |
| NCBI GenInfo Identifier: | 2495724 |
| NCBI Gene ID: | 9663 |
| NCBI Accession: | Q92539.1 |
| UniProt Secondary Accession: | Q92539,A7MD25, D3DUH3, |
| UniProt Related Accession: | Q92539 |
| Molecular Weight: | 99,399 Da |
| NCBI Full Name: | Phosphatidate phosphatase LPIN2 |
| NCBI Synonym Full Names: | lipin 2 |
| NCBI Official Symbol: | LPIN2 |
| NCBI Protein Information: | phosphatidate phosphatase LPIN2 |
| UniProt Protein Name: | Phosphatidate phosphatase LPIN2 |
| UniProt Synonym Protein Names: | Lipin-2 |
| Protein Family: | Phosphatidate phosphatase |
| UniProt Gene Name: | LPIN2 |
| UniProt Entry Name: | LPIN2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LPIN2 antibody (CAB15762) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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