Anti-LMBRD1 Antibody (CAB15866)
- SKU:
- CAB15866
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | Anti-LMBRD1 Antibody |
| Antibody SKU: | CAB15866 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-300 of human LMBRD1 (NP_060838.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG, HeLa, Mouse brain, Mouse lung, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-300 of human LMBRD1 (NP_060838.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PLNL IKGT RSAA YERL ENTE DIEE VEQH IQTI KSKS KDGR PLPA RDKR ALKQ FEER LRTL KKRE RHLE FIEN SWWT KFCG A |
| Gene ID: | 55788 |
| Uniprot: | Q9NUN5 |
| Cellular Location: | Lysosome membrane, Multi-pass membrane protein |
| Calculated MW: | 21kDa/44kDa/53kDa/61kDa |
| Observed MW: | 50kDa |
| Synonyms: | LMBRD1, C6orf209, LMBD1, MAHCF, NESI |
| Background: | This gene encodes a lysosomal membrane protein that may be involved in the transport and metabolism of cobalamin. This protein also interacts with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus. Mutations in this gene are associated with the vitamin B12 metabolism disorder termed, homocystinuria-megaloblastic anemia complementation type F. |
| UniProt Protein Function: | Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV). |
| NCBI Summary: | This gene encodes a lysosomal membrane protein that may be involved in the transport and metabolism of cobalamin. This protein also interacts with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus. Mutations in this gene are associated with the vitamin B12 metabolism disorder termed, homocystinuria-megaloblastic anemia complementation type F.[provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9NUN5 |
| NCBI GenInfo Identifier: | 261878497 |
| NCBI Gene ID: | 55788 |
| NCBI Accession: | NP_060838.3 |
| UniProt Secondary Accession: | Q9NUN5,Q5VUN6, Q86Y70, Q96FW4, Q9BY56, Q9NZD6, A8K204 E1P531, |
| UniProt Related Accession: | Q9NUN5 |
| Molecular Weight: | 21,394 Da |
| NCBI Full Name: | probable lysosomal cobalamin transporter |
| NCBI Synonym Full Names: | LMBR1 domain containing 1 |
| NCBI Official Symbol: | LMBRD1 |
| NCBI Official Synonym Symbols: | NESI; LMBD1; MAHCF; C6orf209 |
| NCBI Protein Information: | probable lysosomal cobalamin transporter |
| UniProt Protein Name: | Probable lysosomal cobalamin transporter |
| UniProt Synonym Protein Names: | HDAg-L-interacting protein NESI; LMBR1 domain-containing protein 1; Nuclear export signal-interacting protein |
| UniProt Gene Name: | LMBRD1 |
 | Western blot analysis of extracts of various cell lines, using LMBRD1 antibody (CAB15866) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunofluorescence analysis of L929 cells using LMBRD1 Rabbit pAb (CAB15866) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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