Anti-LIPC Antibody (CAB13508)

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SKU:
CAB13508
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
Frequently bought together:

Description

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Antibody Name:Anti-LIPC Antibody
Antibody SKU:CAB13508
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 280-499 of human LIPC (NP_000227.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 280-499 of human LIPC (NP_000227.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ERSV HLFI DSLL HAGT QSMA YPCG DMNS FSQG LCLS CKKG RCNT LGYH VRQE PRSK SKRL FLVT RAQS PFKV YHYQ FKIQ FINQ TETP IQTT FTMS LLGT KEKM QKIP ITLG KGIA SNKT YSFL ITLD VDIG ELIM IKFK WENS AVWA NVWD TVQT IIPW STGP RHSG LVLK TIRV KAGE TQQR MTFC SENT DDLL LRPT QEKI FVKC EIKS KTSK RKIR
Gene ID:3990
Uniprot:P11150
Cellular Location:Secreted
Calculated MW:55kDa
Observed MW:Refer to figures
Synonyms:LIPC, HDLCQ12, HL, HTGL, LIPH, lipase C
Background:LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake.
UniProt Protein Function:LIPC: Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin. Defects in LIPC are the cause of hepatic lipase deficiency (HL deficiency). A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins. Belongs to the AB hydrolase superfamily. Lipase family.
UniProt Protein Details:

Protein type:Secreted; EC 3.1.1.3; Secreted, signal peptide; Lipid Metabolism - glycerolipid; Phospholipase

Chromosomal Location of Human Ortholog: 15q21-q23

Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space

Molecular Function:apolipoprotein binding; low-density lipoprotein binding; phospholipase activity; triacylglycerol lipase activity

Biological Process: cholesterol homeostasis; fatty acid biosynthetic process; lipid digestion; reverse cholesterol transport; triacylglycerol catabolic process

Disease: Diabetes Mellitus, Noninsulin-dependent; Hepatic Lipase Deficiency; High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 12

NCBI Summary:LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]
UniProt Code:P11150
NCBI GenInfo Identifier:317373430
NCBI Gene ID:3990
NCBI Accession:P11150.3
UniProt Secondary Accession:P11150,O43571, P78529, Q99465, A2RUB4, A8K9B6,
UniProt Related Accession:P11150
Molecular Weight:55,914 Da
NCBI Full Name:Hepatic triacylglycerol lipase
NCBI Synonym Full Names:lipase C, hepatic type
NCBI Official Symbol:LIPC  
NCBI Official Synonym Symbols:HL; HTGL; LIPH; HDLCQ12  
NCBI Protein Information:hepatic triacylglycerol lipase
UniProt Protein Name:Hepatic triacylglycerol lipase
UniProt Synonym Protein Names:Lipase member C
Protein Family:Spore germination lipase
UniProt Gene Name:LIPC  
UniProt Entry Name:LIPC_HUMAN
Anti-LIPC Antibody (CAB13508)Immunofluorescence analysis of A549 cells using LIPC antibody (CAB13508). Blue: DAPI for nuclear staining.

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