Anti-LI Cadherin/Cadherin-17 Antibody (CAB5286)

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SKU:
CAB5286
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CDH16
HPT-1
HPT1
Frequently bought together:

Description

Product Name:LI Cadherin/Cadherin-17 Rabbit mAb
Product Code:CAB5286
Size:20uL, 50uL, 100uL
Synonyms:CDH16, HPT-1, HPT1
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human LI Cadherin/Cadherin-17
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, Mouse large intestine
Immunogen:A synthesized peptide derived from human LI Cadherin/Cadherin-17
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1015
Uniprot:Q12864
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:120kDa
Observed MW:120kDa
UniProt Protein Function:CDH17: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: basolateral plasma membrane; plasma membrane; integral to membrane

Molecular Function:transporter activity; calcium ion binding; proton-dependent oligopeptide secondary active transmembrane transporter activity

Biological Process: intercellular junction assembly and maintenance; transport; calcium-dependent cell-cell adhesion; cell adhesion; oligopeptide transport; homophilic cell adhesion

NCBI Summary:This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
UniProt Code:Q12864
NCBI GenInfo Identifier:308153624
NCBI Gene ID:1015
NCBI Accession:Q12864.3
UniProt Secondary Accession:Q12864,Q15336, Q2M2E0,
UniProt Related Accession:Q12864
Molecular Weight:92,219 Da
NCBI Full Name:Cadherin-17
NCBI Synonym Full Names:cadherin 17, LI cadherin (liver-intestine)
NCBI Official Symbol:CDH17  
NCBI Official Synonym Symbols:HPT1; CDH16; HPT-1  
NCBI Protein Information:cadherin-17; LI cadherin; LI-cadherin; cadherin-16; HPT-1 cadherin; liver-intestine cadherin; human peptide transporter 1; intestinal peptide-associated transporter HPT-1; human intestinal peptide-associated transporter HPT-1
UniProt Protein Name:Cadherin-17
UniProt Synonym Protein Names:Intestinal peptide-associated transporter HPT-1; Liver-intestine cadherin; LI-cadherin
Protein Family:Cadherin
UniProt Gene Name:CDH17  
UniProt Entry Name:CAD17_HUMAN

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