Anti-Lamin B2 Antibody (CAB5001)

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SKU:
CAB5001
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
EPM9
LAMB2
LMN2
Frequently bought together:

Description

Product Name:Lamin B2 Rabbit mAb
Product Code:CAB5001
Size:20uL, 50uL, 100uL
Synonyms:EPM9, LAMB2, LMN2
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Lamin B2
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, RD, Jurkat
Immunogen:A synthesized peptide derived from human Lamin B2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:84823
Uniprot:Q03252
Cellular Location:Lipid-anchor, Nucleoplasmic side, Nucleus inner membrane
Calculated MW:68kDa
Observed MW:68KDa
UniProt Protein Function:Lamin B2: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Lamin B2 may be lost during the follicle centre stage of B-cell differentiation in humans. Nuclear lamins are cleaved by caspases during apoptosis.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: lamin filament; nuclear inner membrane

Molecular Function:structural molecule activity

Disease: Lipodystrophy, Partial, Acquired, Susceptibility To

UniProt Code:Q03252
NCBI GenInfo Identifier:23503078
NCBI Gene ID:
NCBI Accession:Q03252.3
Molecular Weight:
NCBI Full Name:Lamin-B2
UniProt Protein Name:Lamin-B2
Protein Family:Lamin
UniProt Gene Name:LMNB2  
UniProt Entry Name:LMNB2_HUMAN

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