Anti-L-Plastin/LCP1 Antibody (CAB4664)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문
SKU:
CAB4664
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CP64
Synonyms:
HEL-S-37
Synonyms:
L-PLASTIN
Synonyms:
LC64P
Synonyms:
LPL
Synonyms:
PLS2
€0.00
Frequently bought together:

Description

Product Name:L-Plastin/LCP1 Rabbit mAb
Product Code:CAB4664
Size:20uL, 50uL, 100uL
Synonyms:CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2
Applications:WB, IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human L-Plastin/LCP1
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:Raji
Immunogen:A synthesized peptide derived from human L-Plastin/LCP1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3936
Uniprot:P13796
Calculated MW:70kDa
Observed MW:70KDa
UniProt Protein Function:L-plastin: Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Monomer. Interacts with AIF1. Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T- lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 13q14.3

Cellular Component: actin cytoskeleton; actin filament; actin filament bundle; cytoplasm; cytosol; extracellular space; filopodium; focal adhesion; plasma membrane; podosome; ruffle; stress fiber

Molecular Function:actin filament binding; GTPase binding

Biological Process: actin filament bundle formation; cell migration; extracellular matrix disassembly; regulation of intracellular protein transport; T cell activation during immune response

NCBI Summary:Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]
UniProt Code:P13796
NCBI GenInfo Identifier:308153685
NCBI Gene ID:3936
NCBI Accession:P13796.6
UniProt Secondary Accession:P13796,Q5TBN4, B2R613, B4DUA0,
UniProt Related Accession:P13796
Molecular Weight:21,792 Da
NCBI Full Name:Plastin-2
NCBI Synonym Full Names:lymphocyte cytosolic protein 1
NCBI Official Symbol:LCP1  
NCBI Official Synonym Symbols:LPL; CP64; PLS2; LC64P; HEL-S-37; L-PLASTIN  
NCBI Protein Information:plastin-2
UniProt Protein Name:Plastin-2
UniProt Synonym Protein Names:L-plastin; LC64P; Lymphocyte cytosolic protein 1; LCP-1
Protein Family:Larval cuticle protein
UniProt Gene Name:LCP1  
UniProt Entry Name:PLSL_HUMAN
View AllClose

Related Products