Anti-KLF6 Antibody (CAB10011)

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SKU:
CAB10011
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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Antibody Name:Anti-KLF6 Antibody
Antibody SKU:CAB10011
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-200 of human KLF6 (NP_001291.3).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:PC-3
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-200 of human KLF6 (NP_001291.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ERYL QSEP CYVS ASEI KFDS QEDL WTKI ILAR EKKE ESEL KISS SPPE DTLI SPSF CYNL ETNS LNSD VSSE SSDS SEEL SPTA KFTS DPIG EVLV SSGK LSSS VTST PPSS PELS REPS QLWG CVPG ELPS PGKV RSGT SGKP GDKG NGDA SPDG RRRV H
Gene ID:1316
Uniprot:Q99612
Cellular Location:Nucleus
Calculated MW:26kDa/30kDa/31kDa
Observed MW:45kDa
Synonyms:KLF6, BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9
Background:This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis.
UniProt Protein Function:KLF6: Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development. Defects in KLF6 are a cause of gastric cancer (GASC); also called gastric cancer intestinal or stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. Defects in KLF6 are a cause of prostate cancer (PC). Prostate cancer is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 10p15

Cellular Component: nucleus

Molecular Function:protein binding

Biological Process: positive regulation of transcription, DNA-dependent

Disease: Gastric Cancer; Prostate Cancer

NCBI Summary:This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]
UniProt Code:Q99612
NCBI GenInfo Identifier:7387592
NCBI Gene ID:1316
NCBI Accession:Q99612.3
UniProt Secondary Accession:Q99612,Q5VUT7, Q5VUT8, Q9BT79, B2RE86, B4DDN0, D3DRR1 F5H3M5,
UniProt Related Accession:Q99612
Molecular Weight:26,110 Da
NCBI Full Name:Krueppel-like factor 6
NCBI Synonym Full Names:Kruppel like factor 6
NCBI Official Symbol:KLF6  
NCBI Official Synonym Symbols:GBF; ZF9; BCD1; CBA1; CPBP; PAC1; ST12; COPEB  
NCBI Protein Information:Krueppel-like factor 6
UniProt Protein Name:Krueppel-like factor 6
UniProt Synonym Protein Names:B-cell-derived protein 1; Core promoter element-binding protein; GC-rich sites-binding factor GBF; Proto-oncogene BCD1; Suppressor of tumorigenicity 12 protein; Transcription factor Zf9
Protein Family:Krueppel-like factor
UniProt Gene Name:KLF6  
UniProt Entry Name:KLF6_HUMAN
Anti-KLF6 Antibody (CAB10011)Western blot analysis of extracts of PC-3 cells, using KLF6 antibody (CAB10011) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
Anti-KLF6 Antibody (CAB10011)Immunofluorescence analysis of HeLa cells using KLF6 antibody (CAB10011) at dilution of 1:100. Blue: DAPI for nuclear staining.

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