Anti-KISS1R Antibody (CAB2967)
- SKU:
- CAB2967
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-KISS1R Antibody |
| Antibody SKU: | CAB2967 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human KISS1R |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480 |
| Immunogen: | A synthetic peptide of human KISS1R |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 84634 |
| Uniprot: | Q969F8 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 42kDa |
| Observed MW: | 43kDa |
| Synonyms: | KISS1R, AXOR12, CPPB1, GPR54, HH8, HOT7T175, KISS-1R |
| Background: | The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. |
| UniProt Protein Function: | KISS1R: Receptor for metastin (kisspeptin-54 or kp-54), a C- terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine- tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. Defects in KISS1R are a cause of idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. Defects in KISS1R are a cause of central precocious puberty (CEPREPU). Precocious puberty is defined as the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Central precocious puberty refers to a gonadotropin-dependent type which results from premature activation of the hypothalamic-pituitary-gonadal axis. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; plasma membrane Molecular Function:neuropeptide receptor activity; protein binding Biological Process: G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) Disease: Hypogonadotropic Hypogonadism 8 With Or Without Anosmia; Precocious Puberty, Central, 1 |
| NCBI Summary: | The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q969F8 |
| NCBI GenInfo Identifier: | 125987836 |
| NCBI Gene ID: | 84634 |
| NCBI Accession: | Q969F8.2 |
| UniProt Secondary Accession: | Q969F8,Q96QG0, A5D8U2, B2RTV1, |
| UniProt Related Accession: | Q969F8 |
| Molecular Weight: | 42,586 Da |
| NCBI Full Name: | KiSS-1 receptor |
| NCBI Synonym Full Names: | KISS1 receptor |
| NCBI Official Symbol: | KISS1R |
| NCBI Official Synonym Symbols: | HH8; CPPB1; GPR54; AXOR12; KISS-1R; HOT7T175 |
| NCBI Protein Information: | kiSS-1 receptor |
| UniProt Protein Name: | KiSS-1 receptor |
| UniProt Synonym Protein Names: | G-protein coupled receptor 54; G-protein coupled receptor OT7T175; hOT7T175; Hypogonadotropin-1; Kisspeptins receptor; Metastin receptor |
| Protein Family: | KiSS-1 receptor |
| UniProt Gene Name: | KISS1R |
| UniProt Entry Name: | KISSR_HUMAN |
 | Western blot analysis of extracts of SW480 cells, using KISS1R antibody (CAB2967) at 1:350 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat brain using KISS1R Antibody (CAB2967) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human B cell lymphoma using KISS1R Antibody (CAB2967) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using KISS1R Antibody (CAB2967) at dilution of 1:100 (40x lens). |
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