Anti-KHDRBS1 Antibody (CAB6101)
- SKU:
- CAB6101
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| Antibody Name: | Anti-KHDRBS1 Antibody |
| Antibody SKU: | CAB6101 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human KHDRBS1 (NP_006550.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SKOV3, HeLa, Jurkat, PC-12, Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human KHDRBS1 (NP_006550.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VPRG RGVG PPRG ALVR GTPV RGAI TRGA TVTR GVPP PPTV RGAP APRA RTAG IQRI PLPP PPAP ETYE EYGY DDTY AEQS YEGY EGYY SQSQ GDSE YYDY GHGE VQDS YEAY GQDD WNGT RPSL KAPP ARPV KGAY REHP YGRY |
| Gene ID: | 10657 |
| Uniprot: | Q07666 |
| Cellular Location: | Membrane, Nucleus |
| Calculated MW: | 44kDa/45kDa/48kDa |
| Observed MW: | 68kDa |
| Synonyms: | KHDRBS1, Sam68, p62, p68 |
| Background: | This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | KHDRBS1: a nuclear RNA-binding protein. May be involved in slicing and mRNA transport. Associates with src in mitosis. Binds to RNA via a heteronuclear ribonucleoprotein K homology domain. Exerts functionally separable effects on cell proliferation and survival, dependent on its ability to bind specifically to RNA. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 1p32 Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus Molecular Function:identical protein binding; protein binding; SH3/SH2 adaptor activity; DNA binding; RNA binding; protein complex binding; poly(U) binding; SH3 domain binding; poly(A) binding Biological Process: transcription, DNA-dependent; positive regulation of signal transduction; positive regulation of RNA export from nucleus; regulation of protein stability; signal transduction; positive regulation of translational initiation; cell proliferation; cell surface receptor linked signal transduction; regulation of RNA export from nucleus; mRNA processing; cell cycle arrest; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q07666 |
| NCBI GenInfo Identifier: | 62511098 |
| NCBI Gene ID: | 10657 |
| NCBI Accession: | Q07666.1 |
| UniProt Related Accession: | Q07666 |
| Molecular Weight: | ~ 48kDa |
| NCBI Full Name: | KH domain-containing, RNA-binding, signal transduction-associated protein 1 |
| NCBI Synonym Full Names: | KH RNA binding domain containing, signal transduction associated 1 |
| NCBI Official Symbol: | KHDRBS1 |
| NCBI Official Synonym Symbols: | p62; p68; Sam68 |
| NCBI Protein Information: | KH domain-containing, RNA-binding, signal transduction-associated protein 1 |
| UniProt Protein Name: | KH domain-containing, RNA-binding, signal transduction-associated protein 1 |
| UniProt Synonym Protein Names: | GAP-associated tyrosine phosphoprotein p62; Src-associated in mitosis 68 kDa protein; Sam68; p21 Ras GTPase-activating protein-associated p62; p68 |
| UniProt Gene Name: | KHDRBS1 |
| UniProt Entry Name: | KHDR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KHDRBS1 antibody (CAB6101) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded rat brain using KHDRBS1 antibody (CAB6101) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using KHDRBS1 antibody (CAB6101) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using KHDRBS1 antibody (CAB6101) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse liver using KHDRBS1 antibody (CAB6101) at dilution of 1:100 (40x lens). |
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