Anti-KDM2B Antibody (CAB16017)
- SKU:
- CAB16017
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-KDM2B Antibody |
| Antibody SKU: | CAB16017 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 600-700 of human KDM2B (XP_011537177.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 600-700 of human KDM2B (XP_011537177.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SGCS WIAV SALC SSSC PLLR TLDV QWVE GLKD AQMR DLLS PPTD NRPG QMDN RSKL RNIV ELRL AGLD ITDA SLRL IIRH MPLL SKLH LSYC NHVT DQSI N |
| Gene ID: | 84678 |
| Uniprot: | Q8NHM5 |
| Cellular Location: | |
| Calculated MW: | 63kDa/144kDa/149kDa/151kDa/152kDa |
| Observed MW: | Refer to figures |
| Synonyms: | KDM2B, CXXC2, FBXL10, Fbl10, JHDM1B, PCCX2 |
| Background: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. |
| UniProt Protein Function: | FBXL10: Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Belongs to the JHDM1 histone demethylase family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; EC 1.14.11.27; Demethylase; Nucleolus; Oxidoreductase Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: nucleoplasm; PcG protein complex Molecular Function:histone demethylase activity; protein binding Biological Process: embryonic camera-type eye morphogenesis; forebrain development; fourth ventricle development; hindbrain development; initiation of neural tube closure; lateral ventricle development; midbrain development; midbrain-hindbrain boundary morphogenesis; negative regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; spermatogenesis; third ventricle development |
| NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8NHM5 |
| NCBI GenInfo Identifier: | 51316032 |
| NCBI Gene ID: | 84678 |
| NCBI Accession: | Q8NHM5.1 |
| UniProt Secondary Accession: | Q8NHM5,Q1RLM7, Q8NCI2, Q96HC7, Q96SL0, Q96T03, Q9NS96 Q9UF75, A8MRS1, |
| UniProt Related Accession: | Q8NHM5 |
| Molecular Weight: | 63,630 Da |
| NCBI Full Name: | Lysine-specific demethylase 2B |
| NCBI Synonym Full Names: | lysine demethylase 2B |
| NCBI Official Symbol: | KDM2B |
| NCBI Official Synonym Symbols: | CXXC2; Fbl10; PCCX2; FBXL10; JHDM1B |
| NCBI Protein Information: | lysine-specific demethylase 2B |
| UniProt Protein Name: | Lysine-specific demethylase 2B |
| UniProt Synonym Protein Names: | CXXC-type zinc finger protein 2; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JmjC domain-containing histone demethylation protein 1B; Jumonji domain-containing EMSY-interactor methyltransferase motif protein; Protein JEMMA; Protein-containing CXXC domain 2; [Histone-H3]-lysine-36 demethylase 1B |
| Protein Family: | Lysine-specific demethylase |
| UniProt Gene Name: | KDM2B |
| UniProt Entry Name: | KDM2B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KDM2B antibody (CAB16017) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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