Anti-KCNIP3 Antibody (CAB13711)
- SKU:
- CAB13711
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-KCNIP3 Antibody |
| Antibody SKU: | CAB13711 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNIP3 (NP_038462.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat heart |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNIP3 (NP_038462.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQPA KEVT KASD GSLL GDLG HTPL SKKE GIKW QRPR LSRQ ALMR CCLV KWIL SSTA PQGS DSSD SELE LSTV RHQP EGLD QLQA QTKF TKKE LQSL YRGF |
| Gene ID: | 30818 |
| Uniprot: | Q9Y2W7 |
| Cellular Location: | Cell membrane, Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Lipid-anchor, Nucleus |
| Calculated MW: | 26kDa/29kDa |
| Observed MW: | 29kDa |
| Synonyms: | KCNIP3, CSEN, DREAM, KCHIP3 |
| Background: | This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. |
| UniProt Protein Function: | calsenilin: a small calcium-binding protein. Member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Modulates K4 voltage-gated potassium channels. May regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Also functions as a calcium-regulated transcriptional repressor, and to interact with presenilins. May play a role in the regulation of PSEN2 proteolytic processing. |
| UniProt Protein Details: | Protein type:Transcription factor; Calcium-binding Chromosomal Location of Human Ortholog: 2q21.1 Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; endoplasmic reticulum; dendrite; nerve terminal; nucleus; cytosol Molecular Function:protein C-terminus binding; potassium channel regulator activity; potassium channel activity; DNA binding; sequence-specific DNA binding; voltage-gated ion channel activity; calcium ion binding; calcium-dependent protein binding; transcription corepressor activity Biological Process: regulation of transcription from RNA polymerase II promoter; intracellular protein transport; behavioral response to pain; transcription, DNA-dependent; apoptosis; regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; sensory perception of pain; signal transduction |
| NCBI Summary: | This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y2W7 |
| NCBI GenInfo Identifier: | 13431428 |
| NCBI Gene ID: | 30818 |
| NCBI Accession: | Q9Y2W7.1 |
| UniProt Secondary Accession: | Q9Y2W7,Q3YAC3, Q3YAC4, Q53TJ5, Q96T40, Q9UJ84, Q9UJ85 H7BY46, |
| UniProt Related Accession: | Q9Y2W7 |
| Molecular Weight: | 26,335 Da |
| NCBI Full Name: | Calsenilin |
| NCBI Synonym Full Names: | Kv channel interacting protein 3, calsenilin |
| NCBI Official Symbol: | KCNIP3 |
| NCBI Official Synonym Symbols: | CSEN; DREAM; KCHIP3 |
| NCBI Protein Information: | calsenilin; DRE-antagonist modulator; kv channel-interacting protein 3; potassium channel interacting protein 3; A-type potassium channel modulatory protein 3; calsenilin, presenilin-binding protein, EF hand transcription factor |
| UniProt Protein Name: | Calsenilin |
| UniProt Synonym Protein Names: | A-type potassium channel modulatory protein 3; DRE-antagonist modulator; DREAM; Kv channel-interacting protein 3; KChIP3 |
| Protein Family: | Calsenilin |
| UniProt Gene Name: | KCNIP3 |
| UniProt Entry Name: | CSEN_HUMAN |
 | Western blot analysis of extracts of rat heart, using KCNIP3 antibody (CAB13711) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |