Anti-KCNIP2 Antibody (CAB7100)
- SKU:
- CAB7100
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-KCNIP2 Antibody |
| Antibody SKU: | CAB7100 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human KCNIP2 (NP_775284.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse heart, Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human KCNIP2 (NP_775284.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MRGQ GRKE SLSD SRDL DGSY DQLT GHPP GPTK KALK QRFL KLLP CCGP QALP SVSE NSVD DEFE LSTV CHRP EGLE QLQE QTKF TRKE LQ |
| Gene ID: | 30819 |
| Uniprot: | Q9NS61 |
| Cellular Location: | Cell membrane, Lipid-anchor, Lipid-anchor |
| Calculated MW: | 20kDa/21kDa/25kDa/26kDa/28kDa/30kDa/32kDa |
| Observed MW: | 24kDa |
| Synonyms: | KCNIP2, KCHIP2 |
| Background: | This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. |
| UniProt Protein Function: | KCNIP2: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Belongs to the recoverin family. 9 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 10q24Cellular Component: voltage-gated potassium channel complex; cytoplasmMolecular Function: identical protein binding; protein binding; potassium channel regulator activity; protein N-terminus binding; calcium ion binding; ER retention sequence binding; A-type (transient outward) potassium channel activityBiological Process: synaptic transmission; muscle contraction; clustering of voltage-gated potassium channels; detection of calcium ion; signal transduction; regulation of heart contraction; potassium ion transport |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NS61 |
| NCBI GenInfo Identifier: | 338817979 |
| NCBI Gene ID: | 30819 |
| NCBI Accession: | Q9NS61.3 |
| UniProt Secondary Accession: | Q9NS61 |
| UniProt Related Accession: | Q9NS61 |
| Molecular Weight: | 24kDa |
| NCBI Full Name: | Kv channel-interacting protein 2 |
| NCBI Synonym Full Names: | potassium voltage-gated channel interacting protein 2 |
| NCBI Official Symbol: | KCNIP2 |
| NCBI Official Synonym Symbols: | KCHIP2 |
| NCBI Protein Information: | Kv channel-interacting protein 2 |
| UniProt Protein Name: | Kv channel-interacting protein 2 |
| UniProt Synonym Protein Names: | A-type potassium channel modulatory protein 2; Cardiac voltage-gated potassium channel modulatory subunit; Potassium channel-interacting protein 2 |
| Protein Family: | Kv channel-interacting protein |
| UniProt Gene Name: | KCNIP2 |
| UniProt Entry Name: | KCIP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KCNIP2 antibody (CAB7100) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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