Anti-KCNH7 항체 (CAB15923)

Antibody Name:	Anti-KCNH7 Antibody
Antibody SKU:	CAB15923
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 100-350 of human KCNH7 (NP_775185.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse
Positive Samples:	Mouse brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 100-350 of human KCNH7 (NP_775185.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	HKNG STFI CNTH IIPV KNQE GVAM MFII NFEY VTDN ENAA TPER VNPI LPIK TVNR KFFG FKFP GLRV LTYR KQSL PQED PDVV VIDS SKHS DDSV AMKH FKSP TKES CSPS EADD TKAL IQPS KCSP LVNI SGPL DHSS PKRQ WDRL YPDM LQSS SQLS HSRS RESL CSIR RASS VHDI EGFG VHPK NIFR DRHA SEGP FNHI KSSL LGST SDSN LNKY STIN KIPQ LTLN FSEV KTEK KNSS PPSS DKT
Gene ID:	90134
Uniprot:	Q9NS40
Cellular Location:	Membrane, Multi-pass membrane protein
Calculated MW:	82kDa/135kDa
Observed MW:	135kDa

Synonyms:

KCNH7, ERG3, HERG3, Kv11.3

Background:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms.

UniProt Protein Function:	Kv11.3: Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 2q24.2 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:voltage-gated potassium channel activity Biological Process: regulation of membrane potential
NCBI Summary:	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9NS40
NCBI GenInfo Identifier:	229462892
NCBI Gene ID:	90134
NCBI Accession:	Q9NS40.2
UniProt Secondary Accession:	Q9NS40,Q53QU4, Q53TB7, Q53TP9, Q8IV15,
UniProt Related Accession:	Q9NS40
Molecular Weight:	82,904 Da
NCBI Full Name:	Potassium voltage-gated channel subfamily H member 7
NCBI Synonym Full Names:	potassium voltage-gated channel subfamily H member 7
NCBI Official Symbol:	KCNH7
NCBI Official Synonym Symbols:	ERG3; HERG3; Kv11.3
NCBI Protein Information:	potassium voltage-gated channel subfamily H member 7
UniProt Protein Name:	Potassium voltage-gated channel subfamily H member 7
UniProt Synonym Protein Names:	Ether-a-go-go-related gene potassium channel 3; ERG-3; Eag-related protein 3; Ether-a-go-go-related protein 3; hERG-3; Voltage-gated potassium channel subunit Kv11.3
Protein Family:	Potassium voltage-gated channel subfamily
UniProt Gene Name:	KCNH7
UniProt Entry Name:	KCNH7_HUMAN

Western blot analysis of extracts of mouse brain, using KCNH7 antibody (CAB15923) at 1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

Antibodies

KCNH7 Antibody (PACO10052)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)