Anti-KCNAB2 Antibody (CAB16224)
- SKU:
- CAB16224
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-KCNAB2 Antibody |
| Antibody SKU: | CAB16224 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-40 of human KCNAB2 (NP_003627.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-40 of human KCNAB2 (NP_003627.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MYPE STTG SPAR LSLR QTGS PGMI YSTR YGSP KRQL QFYR |
| Gene ID: | 8514 |
| Uniprot: | Q13303 |
| Cellular Location: | |
| Calculated MW: | 33kDa/39kDa/41kDa/43kDa/46kDa |
| Observed MW: | 46kDa |
| Synonyms: | KCNAB2, AKR6A5, HKvbeta2, HKvbeta2.1, HKvbeta2.2, KCNA2B, KV-BETA-2 |
| Background: | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. |
| NCBI Summary: | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q13303 |
| NCBI GenInfo Identifier: | 18202496 |
| NCBI Gene ID: | 8514 |
| NCBI Accession: | Q13303.2 |
| UniProt Related Accession: | Q13303 |
| Molecular Weight: | 33kDa; 39kDa; 41kDa; 43kDa; 46kDa |
| NCBI Full Name: | Voltage-gated potassium channel subunit beta-2 |
| NCBI Synonym Full Names: | potassium voltage-gated channel subfamily A regulatory beta subunit 2 |
| NCBI Official Symbol: | KCNAB2 |
| NCBI Official Synonym Symbols: | AKR6A5; KCNA2B; HKvbeta2; KV-BETA-2; HKvbeta2.1; HKvbeta2.2 |
| NCBI Protein Information: | voltage-gated potassium channel subunit beta-2 |
| UniProt Protein Name: | Voltage-gated potassium channel subunit beta-2 |
| UniProt Synonym Protein Names: | K(+) channel subunit beta-2; Kv-beta-2 |
| Protein Family: | Voltage-gated potassium channel |
| UniProt Gene Name: | KCNAB2 |
| UniProt Entry Name: | KCAB2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KCNAB2 antibody (CAB16224) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunofluorescence analysis of L929 cells using KCNAB2 antibody (CAB16224) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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