Anti-KANK2 Antibody (CAB15420)
- SKU:
- CAB15420
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-KANK2 Antibody |
| Antibody SKU: | CAB15420 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human KANK2 (NP_001129663.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse skeletal muscle, Mouse heart, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human KANK2 (NP_001129663.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAQV LHVP APFP GTPG PASP PAFP AKDP DPPY SVET PYGY RLDL DFLK YVDD IEKG HTLR RVAV QRRP RLSS LPRG PGSW WTST ESLC SNAS GDSR HSAY SYCG RGFY PQYG ALET RGGF NPRV ERTL LDAR RRLE DQAA TPTG LGSL TPSA AGST ASLV GVGL PPPT PRSS GLST PVPP SAGH LAHV REQM AGAL RKLR QLEE QVKL IPVL QVKL SVLQ EEKR QLTV QLKS QKFL GHPT AGRG RSEL CLDL PDPP EDPV ALET RSVG TWVR ERDL GMPD GEAA LAAK VAVL ETQL KKAL |
| Gene ID: | 25959 |
| Uniprot: | Q63ZY3 |
| Cellular Location: | Cytoplasm, Mitochondrion |
| Calculated MW: | 90kDa/91kDa |
| Observed MW: | 100kDa |
| Synonyms: | KANK2, ANKRD25, MXRA3, PPKWH, SIP |
| Background: | This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. |
| UniProt Protein Function: | Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500). May be involved in promotion of cell proliferation. |
| UniProt Code: | Q63ZY3 |
| NCBI GenInfo Identifier: | 74757262 |
| NCBI Gene ID: | 25959 |
| NCBI Accession: | Q63ZY3.1 |
| UniProt Secondary Accession: | Q63ZY3,Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210, B0I1P4 |
| UniProt Related Accession: | Q63ZY3 |
| Molecular Weight: | 90,044 Da |
| NCBI Full Name: | KN motif and ankyrin repeat domain-containing protein 2 |
| NCBI Synonym Full Names: | KN motif and ankyrin repeat domains 2 |
| NCBI Official Symbol: | KANK2 |
| NCBI Official Synonym Symbols: | SIP; MXRA3; PPKWH; ANKRD25 |
| NCBI Protein Information: | KN motif and ankyrin repeat domain-containing protein 2 |
| UniProt Protein Name: | KN motif and ankyrin repeat domain-containing protein 2 |
| UniProt Synonym Protein Names: | Ankyrin repeat domain-containing protein 25; Matrix-remodeling-associated protein 3; SRC-1-interacting protein; SIP; SRC-interacting protein; SRC1-interacting protein |
| Protein Family: | KN motif and ankyrin repeat domain-containing protein |
| UniProt Gene Name: | KANK2 |
| UniProt Entry Name: | KANK2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KANK2 antibody (CAB15420) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
 | Immunohistochemistry of paraffin-embedded rat ovary using KANK2 antibody (CAB15420) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat pancreas using KANK2 antibody (CAB15420) at dilution of 1:100 (40x lens). |
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