| Synonyms: | KDM5B, CT31, JARID1B, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A, RBP2-H1 |
| UniProt Protein Function: | JARID1B: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Demethylase; Cancer Testis Antigen (CTA); EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:histone demethylase activity; histone demethylase activity (H3-K4 specific); protein binding; transcription corepressor activity; transcription factor activity |
| NCBI Summary: | This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing resultsi n multiple transcript variants. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q9UGL1 |
| NCBI GenInfo Identifier: | 296439317 |
| NCBI Gene ID: | 10765 |
| NCBI Accession: | Q9UGL1.3 |
| UniProt Secondary Accession: | Q9UGL1,O95811, Q15752, Q9Y3Q5, |
| UniProt Related Accession: | Q9UGL1 |
| Molecular Weight: | 179,409 Da |
| NCBI Full Name: | Lysine-specific demethylase 5B |
| NCBI Synonym Full Names: | lysine demethylase 5B |
| NCBI Official Symbol: | KDM5B |
| NCBI Official Synonym Symbols: | CT31; PLU1; PUT1; PLU-1; JARID1B; PPP1R98; RBP2-H1; RBBP2H1A |
| NCBI Protein Information: | lysine-specific demethylase 5B |
| UniProt Protein Name: | Lysine-specific demethylase 5B |
| UniProt Synonym Protein Names: | Cancer/testis antigen 31; CT31; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; PLU-1; Retinoblastoma-binding protein 2 homolog 1; RBP2-H1 |
| Protein Family: | Lysine-specific demethylase |
| UniProt Gene Name: | KDM5B |
| UniProt Entry Name: | KDM5B_HUMAN |
