Anti-JAK1 Antibody (CAB11963)

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SKU:
CAB11963
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
JAK1A
JAK1B
JTK3
Frequently bought together:

Description

Product Name:JAK1 Rabbit mAb
Product Code:CAB11963
Size:20uL, 50uL, 100uL
Synonyms:JAK1A, JAK1B, JTK3
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human JAK1
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse lung
Immunogen:A synthesized peptide derived from human JAK1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3716
Uniprot:P23458
Calculated MW:133kDa
Observed MW:130KDa
UniProt Protein Function:JAK1: a widely expressed non-receptor tyrosine-kinase involved in the interferon-alpha/beta and -gamma signal transduction pathways. Couples cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. A selective Jak1 inhibitor induces apoptosis in NRP-154 prostate cancer cell line. A single mutation seen in tyrosine kinome screen of colon cancers. Activated in B cell lines from patients with post-transplant lymphoproliferative disorder, and in a mouse Lck-driven T cell lymphoma. Inhibitor: Piceatannol.
UniProt Protein Details:

Protein type:Kinase, protein; EC 2.7.10.2; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; JakA family

Chromosomal Location of Human Ortholog: 1p32.3-p31.3

Cellular Component: cytoplasm; cytoskeleton; cytosol; endomembrane system; extrinsic to internal side of plasma membrane; focal adhesion; nucleus

Molecular Function:ATP binding; CCR5 chemokine receptor binding; growth hormone receptor binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein phosphatase binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding; ubiquitin protein ligase binding

Biological Process: cell differentiation; cell migration; innate immune response; MAPKKK cascade; positive regulation of GTPase activity; protein amino acid phosphorylation; regulation of cell proliferation; response to antibiotic; transmembrane receptor protein tyrosine kinase signaling pathway

NCBI Summary:This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Code:P23458
NCBI GenInfo Identifier:215274013
NCBI Gene ID:3716
NCBI Accession:P23458.2
UniProt Secondary Accession:P23458,Q59GQ2, Q9UD26,
UniProt Related Accession:P23458
Molecular Weight:
NCBI Full Name:Tyrosine-protein kinase JAK1
NCBI Synonym Full Names:Janus kinase 1
NCBI Official Symbol:JAK1  
NCBI Official Synonym Symbols:JTK3; JAK1A; JAK1B  
NCBI Protein Information:tyrosine-protein kinase JAK1
UniProt Protein Name:Tyrosine-protein kinase JAK1
UniProt Synonym Protein Names:Janus kinase 1; JAK-1
Protein Family:Tyrosine-protein kinase
UniProt Gene Name:JAK1  
UniProt Entry Name:JAK1_HUMAN

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