Anti-JADE1 Antibody (CAB6337)
- SKU:
- CAB6337
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-JADE1 Antibody |
| Antibody SKU: | CAB6337 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-509 of human JADE1 (NP_079176.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse kidney, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-509 of human JADE1 (NP_079176.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QSPD GEDG NEMV FCDK CNIC VHQA CYGI LKVP EGSW LCRT CALG VQPK CLLC PKKG GAMK PTRS GTKW VHVS CALW IPEV SIGS PEKM EPIT KVSH IPSS RWAL VCSL CNEK FGAS IQCS VKNC RTAF HVTC AFDR GLEM KTIL AEND EVKF KSYC PKHS SHRK PEES LGKG AAQE NGAP ECSP RNPL EPFA SLEQ NREE AHRV SVRK QKLQ QLED EFYT FVNL LDVA RALR LPEE VVDF LYQY WKLK RKVN FNKP LITP KKDE EDNL AKRE QDVL FRRL QLFT HLRQ DLER VMID TDTL |
| Gene ID: | 79960 |
| Uniprot: | Q6IE81 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 58kDa/94kDa/95kDa |
| Observed MW: | 108kDa |
| Synonyms: | JADE1, PHF17 |
| Background: |
| UniProt Protein Function: | JADE1: Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Belongs to the JADE family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: 4q26-q27 Cellular Component: cytoplasm; histone acetyltransferase complex; nucleoplasm; nucleus; plasma membrane Molecular Function:protein binding |
| UniProt Code: | Q6IE81 |
| NCBI GenInfo Identifier: | 74748786 |
| NCBI Gene ID: | 79960 |
| NCBI Accession: | Q6IE81.1 |
| UniProt Secondary Accession: | Q6IE81,Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692 D3DNY0, D3DNY1, |
| UniProt Related Accession: | Q6IE81 |
| Molecular Weight: | 58,370 Da |
| NCBI Full Name: | Protein Jade-1 |
| NCBI Synonym Full Names: | jade family PHD finger 1 |
| NCBI Official Symbol: | JADE1 |
| NCBI Official Synonym Symbols: | PHF17 |
| NCBI Protein Information: | protein Jade-1 |
| UniProt Protein Name: | Protein Jade-1 |
| UniProt Synonym Protein Names: | Jade family PHD finger protein 1; PHD finger protein 17 |
| Protein Family: | Protein |
| UniProt Gene Name: | JADE1 |
| UniProt Entry Name: | JADE1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using JADE1 antibody (CAB6337) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunofluorescence analysis of U2OS cells using JADE1 antibody (CAB6337). Blue: DAPI for nuclear staining. |
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