Anti-ITGB3BP Antibody (CAB14859)
- SKU:
- CAB14859
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-ITGB3BP Antibody |
| Antibody SKU: | CAB14859 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-111 of human ITGB3BP (NP_055103.3). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-111 of human ITGB3BP (NP_055103.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPVK RSLK LDGL LEEN SFDP SKIT RKKS VITY SPTT GTCQ MSLF ASPT SSEE QKHR NGLS NEKR KKLN HPSL TESK ESTT KDND EFMM LLSK VEKL SEEI MEIM QNLS SIQ |
| Gene ID: | 23421 |
| Uniprot: | Q13352 |
| Cellular Location: | Chromosome, Cytoplasm, Cytoplasm, Nucleus, centromere, kinetochore |
| Calculated MW: | 6kDa/12kDa/19kDa/20kDa/24kDa |
| Observed MW: |
| Synonyms: | ITGB3BP, CENP-R, CENPR, HSU37139, NRIF3, TAP20 |
| Background: | This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | NRIF3: Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A- associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Homodimer; mediated by the coiled coil domain. Isoform 3, but not other isoforms, interacts with the cytoplasmic tail of integrin ITGB3. The relevance of the interaction with ITGB3 is however uncertain, since isoform 3 is mainly nuclear. Interacts with CCNA2 and MTA1. Interacts with NFKB1 NF-kappa-B subunit. Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. By estrogen. Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus; cytosol Molecular Function:protein C-terminus binding; signal transducer activity Biological Process: mitosis; nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; nerve growth factor receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of apoptosis; cell division; mitotic cell cycle; cell adhesion; signal transduction |
| NCBI Summary: | This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q13352 |
| NCBI GenInfo Identifier: | 50400855 |
| NCBI Gene ID: | 23421 |
| NCBI Accession: | Q13352.2 |
| UniProt Secondary Accession: | Q13352,Q9CQ82, Q5U1Z7, |
| UniProt Related Accession: | Q13352 |
| Molecular Weight: | 177 |
| NCBI Full Name: | Centromere protein R |
| NCBI Synonym Full Names: | integrin beta 3 binding protein (beta3-endonexin) |
| NCBI Official Symbol: | ITGB3BP |
| NCBI Official Synonym Symbols: | CENPR; NRIF3; TAP20; CENP-R; HSU37139 |
| NCBI Protein Information: | centromere protein R; beta 3 endonexin; beta-3-endonexin; integrin beta-3-binding protein; nuclear receptor-interacting factor 3 |
| UniProt Protein Name: | Centromere protein R |
| UniProt Synonym Protein Names: | Beta-3-endonexin; Integrin beta-3-binding protein; Nuclear receptor-interacting factor 3 |
| UniProt Gene Name: | ITGB3BP |
| UniProt Entry Name: | CENPR_HUMAN |
 | Immunohistochemistry of paraffin-embedded human liver using ITGB3BP antibody (CAB14859) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human appendix using ITGB3BP antibody (CAB14859) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using ITGB3BP antibody (CAB14859) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using ITGB3BP antibody (CAB14859) at dilution of 1:100 (40x lens). |
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