Anti-ITGB3 Antibody (MACO0246)
- SKU:
- MACO0246
- Product type:
- Antibody
- Reactivity:
- Human
- Dog
- Rabbit
- Rat
- Mouse
- Host Species:
- Mouse
- Isotype:
- IgG1
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Monoclonal Antibody
- Conjugation:
- Unconjugated
Description
| Product Name: | Anti-ITGB3 Antibody |
| Product Sku: | MACO0246 |
| Size: | 100ul |
| Host Species: | Mouse |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:5000 |
| Species Reactivity: | Human, Dog, Rabbit, Rat, Mouse |
| Immunogen: | Purified recombinant human ITGB3 protein fragments expressed in E.coli. |
| Form: | Liquid |
| Storage Buffer: | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol |
| Purification Method: | Affinity purified |
| Clonality: | Monoclonal |
| Isotype: | IgG1 |
| Conjugate: | Non-conjugated |
| Background: | Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin. |
| Synonyms: | GT, CD61, GP3A, BDPLT2, GPIIIa |
| UniProt Protein Function: | ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 17q21.32 Cellular Component: cell surface; filopodium membrane; focal adhesion; integral to plasma membrane; integrin complex; melanosome; microvillus membrane; nucleus; plasma membrane; platelet alpha granule membrane; receptor complex Molecular Function:C-X3-C chemokine binding; cell adhesion molecule binding; coreceptor activity; enzyme binding; extracellular matrix binding; fibroblast growth factor binding; fibronectin binding; identical protein binding; insulin-like growth factor I binding; platelet-derived growth factor receptor binding; protease binding; protein binding; protein disulfide isomerase activity; vascular endothelial growth factor receptor 2 binding Biological Process: activation of protein kinase activity; angiogenesis involved in wound healing; blood coagulation; cell adhesion; cell growth; cell migration; cell-matrix adhesion; cell-substrate adhesion; entry of virus into host cell; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte migration; mesodermal cell differentiation; negative chemotaxis; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor biosynthetic process; platelet activation; platelet degranulation; positive regulation of endothelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; regulation of bone resorption; smooth muscle cell migration; tube development; vascular endothelial growth factor receptor signaling pathway; wound healing Disease: Bleeding Disorder, Platelet-type, 16; Glanzmann Thrombasthenia; Myocardial Infarction, Susceptibility To |
| NCBI Summary: | The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05106 |
| NCBI GenInfo Identifier: | 125987835 |
| NCBI Gene ID: | 3690 |
| NCBI Accession: | P05106.2 |
| UniProt Secondary Accession: | P05106,O15495, Q12806, Q13413, Q14648, Q16499, A0PJW2 D3DXJ8, |
| UniProt Related Accession: | P05106 |
| Molecular Weight: | 86,694 Da |
| NCBI Full Name: | Integrin beta-3 |
| NCBI Synonym Full Names: | integrin subunit beta 3 |
| NCBI Official Symbol: | ITGB3 |
| NCBI Official Synonym Symbols: | GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16 |
| NCBI Protein Information: | integrin beta-3 |
| UniProt Protein Name: | Integrin beta-3 |
| UniProt Synonym Protein Names: | Platelet membrane glycoprotein IIIa; GPIIIa; CD_antigen: CD61 |
| Protein Family: | Integrin |
| UniProt Gene Name: | ITGB3 |
| UniProt Entry Name: | ITB3_HUMAN |
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