Anti-ITGA8 Antibody (CAB13056)
- SKU:
- CAB13056
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-ITGA8 Antibody |
| Antibody SKU: | CAB13056 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 907-1000 of human ITGA8 (NP_003629.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, LO2, Mouse spleen, Mouse testis, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 907-1000 of human ITGA8 (NP_003629.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DVHV VEFH RQSP AKIL NCTN IECL QISC AVGR LEGG ESAV LKVR SRLW AHTF LQRK NDPY ALAS LVSF EVKK MPYT DQPA KLPE GSIV IKTS VI |
| Gene ID: | 8516 |
| Uniprot: | P53708 |
| Cellular Location: | Cell membrane, Membrane, Single-pass type I membrane protein |
| Calculated MW: | 117kDa |
| Observed MW: | 117kDa |
| Synonyms: | ITGA8 |
| Background: | Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. |
| UniProt Protein Function: | ITGA8: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. Belongs to the integrin alpha chain family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 10p13 Cellular Component: cell surface; endoplasmic reticulum; focal adhesion; integrin complex; plasma membrane Biological Process: cell-matrix adhesion; extracellular matrix organization and biogenesis; kidney development; mesodermal cell differentiation Disease: Renal Hypodysplasia/aplasia 1 |
| NCBI Summary: | Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014] |
| UniProt Code: | P53708 |
| NCBI GenInfo Identifier: | 311033437 |
| NCBI Gene ID: | 8516 |
| NCBI Accession: | P53708.3 |
| UniProt Secondary Accession: | P53708,Q5VX94, B0YJ31, |
| UniProt Related Accession: | P53708 |
| Molecular Weight: | 117,474 Da |
| NCBI Full Name: | Integrin alpha-8 |
| NCBI Synonym Full Names: | integrin subunit alpha 8 |
| NCBI Official Symbol: | ITGA8 |
| NCBI Protein Information: | integrin alpha-8 |
| UniProt Protein Name: | Integrin alpha-8 |
| Protein Family: | Integrin |
| UniProt Gene Name: | ITGA8 |
| UniProt Entry Name: | ITA8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ITGA8 antibody (CAB13056) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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