Anti-ISG15 Antibody (CAB2416)
- SKU:
- CAB2416
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | Anti-ISG15 Antibody |
| Antibody SKU: | CAB2416 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ISG15 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse spleen, Rat lung |
| Immunogen: | A synthesized peptide derived from human ISG15 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9636 |
| Uniprot: | P05161 |
| Cellular Location: | |
| Calculated MW: | 15kDa |
| Observed MW: | 15KDa |
| Synonyms: | G1P2, IFI15, IMD38, IP17, UCRP, hUCRP |
| Background: | The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012] |
| UniProt Protein Function: | ISG15: Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections. Interacts with, and is conjugated to its targets by the UBE1L (E1 enzyme) and UBE2E2 (E2 enzyme) (Probable). Interaction with influenza B NS1 protein inhibits this conjugation. By type I interferons. Detected in lymphoid cells, striated and smooth muscle, several epithelia and neurons. |
| UniProt Protein Details: | Protein type:Ubiquitin-like modifier Chromosomal Location of Human Ortholog: 1p36.33 Cellular Component: cytosol; extracellular region; nucleoplasm Molecular Function:protein binding Biological Process: bypass DNA synthesis; defense response to bacterium; defense response to virus; ISG15-protein conjugation; negative regulation of interferon type I production; negative regulation of protein ubiquitination; negative regulation of viral genome replication; positive regulation of bone mineralization; regulation of interferon-gamma production Disease: Immunodeficiency 38 |
| NCBI Summary: | The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012] |
| UniProt Code: | P05161 |
| NCBI GenInfo Identifier: | 52001470 |
| NCBI Gene ID: | 9636 |
| NCBI Accession: | P05161.5 |
| UniProt Secondary Accession: | P05161,Q5SVA4, Q7Z2G2, Q96GF0, |
| UniProt Related Accession: | P05161 |
| Molecular Weight: | 17,888 Da |
| NCBI Full Name: | Ubiquitin-like protein ISG15 |
| NCBI Synonym Full Names: | ISG15 ubiquitin-like modifier |
| NCBI Official Symbol: | ISG15 |
| NCBI Official Synonym Symbols: | G1P2; IP17; UCRP; IFI15; IMD38; hUCRP |
| NCBI Protein Information: | ubiquitin-like protein ISG15 |
| UniProt Protein Name: | Ubiquitin-like protein ISG15 |
| UniProt Synonym Protein Names: | Interferon-induced 15 kDa protein; Interferon-induced 17 kDa protein; IP17; Ubiquitin cross-reactive protein; hUCRP |
| Protein Family: | Ubiquitin-like protein |
| UniProt Gene Name: | ISG15 |
 | Western blot - ISG15 Rabbit mAb (CAB2416) |
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Human ISG15 ELISA Kit
