Anti-IRF6 Antibody (CAB6246)

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SKU:
CAB6246
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology
Frequently bought together:

Description

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Antibody Name:Anti-IRF6 Antibody
Antibody SKU:CAB6246
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 115-300 of human IRF6 (NP_006138.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:22Rv1, BT-474, HT-29, MCF7, 293T, Mouse liver, Mouse kidney, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 115-300 of human IRF6 (NP_006138.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DIPQ PQGS IINP GSTG SAPW DEKD NDVD EEDE EDEL DQSQ HHVP IQDT FPFL NING SPMA PASV GNCS VGNC SPEA VWPK TEPL EMEV PQAP IQPF YSSP ELWI SSLP MTDL DIKF QYRG KEYG QTMT VSNP QGCR LFYG DLGP MPDQ EELF GPVS LEQV KFPG PEHI TNEK QKLF TSKL LDVM DR
Gene ID:3664
Uniprot:O14896
Cellular Location:Cytoplasm, Nucleus
Calculated MW:41kDa/53kDa
Observed MW:53kDa
Synonyms:IRF6, LPS, OFC6, PIT, PPS, PPS1, VWS, VWS1
Background:This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:IRF6: Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Interacts with SERPINB5. Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. Belongs to the IRF family.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 1q32.3-q41

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function:protein binding; DNA binding; transcription factor activity

Biological Process: keratinocyte differentiation; negative regulation of cell proliferation; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; keratinocyte proliferation; cell cycle arrest; cell development

Disease: Orofacial Cleft 6, Susceptibility To; Popliteal Pterygium Syndrome; Van Der Woude Syndrome 1

NCBI Summary:This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]
UniProt Code:O14896
NCBI GenInfo Identifier:3122293
NCBI Gene ID:3664
NCBI Accession:O14896.1
UniProt Secondary Accession:O14896,B4DLE2, D3DT90, F5GWX8, G0ZTL0,
UniProt Related Accession:O14896
Molecular Weight:467
NCBI Full Name:Interferon regulatory factor 6
NCBI Synonym Full Names:interferon regulatory factor 6
NCBI Official Symbol:IRF6  
NCBI Official Synonym Symbols:LPS; PIT; PPS; VWS; OFC6; PPS1; VWS1  
NCBI Protein Information:interferon regulatory factor 6
UniProt Protein Name:Interferon regulatory factor 6
Protein Family:Interferon regulatory factor
UniProt Gene Name:IRF6  
UniProt Entry Name:IRF6_HUMAN
Anti-IRF6 Antibody (CAB6246)Western blot analysis of extracts of various cell lines, using IRF6 antibody (CAB6246) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 15s.

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