Anti-IQGAP2 Antibody (CAB15392)
- SKU:
- CAB15392
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-IQGAP2 Antibody |
| Antibody SKU: | CAB15392 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1330-1440 of human IQGAP2 (NP_006624.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1330-1440 of human IQGAP2 (NP_006624.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QQEV DHAT DMVS RAMI DSRT PEEM KHSQ SMIE DAQL PLEQ KKRK IQRN LRTL EQTG HVSS ENKY QDIL NEIA KDIR NQRI YRKL RKAE LAKL QQTL NALN KKAA FYEE QIN |
| Gene ID: | 10788 |
| Uniprot: | Q13576 |
| Cellular Location: | |
| Calculated MW: | 122kDa/180kDa |
| Observed MW: | 180kDa |
| Synonyms: | IQGAP2 |
| Background: | This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. |
| NCBI Summary: | This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13576 |
| NCBI GenInfo Identifier: | 292495090 |
| NCBI Gene ID: | 10788 |
| NCBI Accession: | Q13576.4 |
| UniProt Secondary Accession: | Q13576,A8K4V1, B7Z8A4, J3KR91, |
| UniProt Related Accession: | Q13576 |
| Molecular Weight: | 122,806 Da |
| NCBI Full Name: | Ras GTPase-activating-like protein IQGAP2 |
| NCBI Synonym Full Names: | IQ motif containing GTPase activating protein 2 |
| NCBI Official Symbol: | IQGAP2 |
| NCBI Protein Information: | ras GTPase-activating-like protein IQGAP2 |
| UniProt Protein Name: | Ras GTPase-activating-like protein IQGAP2 |
| Protein Family: | Ras GTPase-activating-like protein |
| UniProt Gene Name: | IQGAP2 |
| UniProt Entry Name: | IQGA2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IQGAP2 antibody (CAB15392) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Immunohistochemistry of paraffin-embedded Human breast cancer using IQGAP2 Rabbit pAb (CAB15392) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Rat kidney using IQGAP2 Rabbit pAb (CAB15392) at dilution of 1:100 (40x lens). |
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