Anti-IPO9 Antibody (CAB12233)
- SKU:
- CAB12233
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-IPO9 Antibody |
| Antibody SKU: | CAB12233 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 827-1041 of human IPO9 (NP_060555.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, Mouse brain, Mouse lung, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 827-1041 of human IPO9 (NP_060555.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LPGP TGKP ALEF VMAE WTSR QHLF YGQY EGKV SSVA LCKL LQHG INAD DKRL QDIR VKGE EIYS MDEG IRTR SKSA KNPE RWTN IPLL VKIL KLII NELS NVME ANAA RQAT PAEW SQDD SNDM WEDQ EEEE EEEE DGLA GQLL SDIL ATSK YEED YYED DEED DPDA LKDP LYQI DLQA YLTD FLCQ FAQQ PCYI MFSG HLND NERR VLQT IGI |
| Gene ID: | 55705 |
| Uniprot: | Q96P70 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 115kDa |
| Observed MW: | 116kDa |
| Synonyms: | IPO9, Imp9 |
| Background: |
| UniProt Protein Function: | IPO9: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of H2B histone, RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones, RPL4 and RPL6. Belongs to the importin beta family. |
| UniProt Protein Details: | Protein type:Karyopherin; Nuclear import Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: cytoplasm; membrane Molecular Function:histone binding; protein binding; protein transporter activity |
| UniProt Code: | Q96P70 |
| NCBI GenInfo Identifier: | 41688593 |
| NCBI Gene ID: | 55705 |
| NCBI Accession: | Q96P70.3 |
| UniProt Secondary Accession: | Q96P70,Q8N1Y1, Q8N3I2, Q8NCG9, Q96SU6, Q9NW01, Q9P0A8 Q9ULM8, B1ASV5, |
| UniProt Related Accession: | Q96P70 |
| Molecular Weight: | 116kDa |
| NCBI Full Name: | Importin-9 |
| NCBI Synonym Full Names: | importin 9 |
| NCBI Official Symbol: | IPO9 |
| NCBI Official Synonym Symbols: | Imp9 |
| NCBI Protein Information: | importin-9 |
| UniProt Protein Name: | Importin-9 |
| UniProt Synonym Protein Names: | Ran-binding protein 9; RanBP9 |
| Protein Family: | Importin |
| UniProt Gene Name: | IPO9 |
 | Western blot analysis of extracts of various cell lines, using IPO9 antibody (CAB12233) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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