Anti-IPO13 Antibody (CAB16472)
- SKU:
- CAB16472
- Product type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-IPO13 Antibody |
| Antibody SKU: | CAB16472 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 764-963 of human IPO13 (NP_055467.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 764-963 of human IPO13 (NP_055467.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IEAL FLLV TSVT LTLF QQGP RDHP DIVD SFMQ LLAQ ALKR KPDL FLCE RLDV KAVF QCAV LALK FPEA PTVK ASCG FFTE LLPR CGEV ESVG KVVQ EDGR MLLI AVLE AIGG QASR SLMD CFAD ILFA LNKH CFSL LSMW IKEA LQPP GFPS ARLS PEQK DTFS QQIL RERV NKRR VKEM VKEF TLLC RGLH GTDY TADY |
| Gene ID: | 9670 |
| Uniprot: | O94829 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 108kDa |
| Observed MW: | 100kDa |
| Synonyms: | IPO13, IMP13, KAP13, LGL2, RANBP13 |
| Background: | This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A. |
| UniProt Protein Function: | IPO13: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13. Belongs to the importin beta family. |
| UniProt Protein Details: | Protein type:Nuclear export; Nuclear import; Karyopherin Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; Ran GTPase binding Biological Process: protein import into nucleus |
| UniProt Code: | O94829 |
| NCBI GenInfo Identifier: | 50400817 |
| NCBI Gene ID: | |
| NCBI Accession: | O94829.3 |
| Molecular Weight: | Predicted Molecular Mass: 24.9kDaAccurate Molecular Mass: 25kDa |
| NCBI Full Name: | Importin-13 |
| UniProt Protein Name: | Importin-13 |
| UniProt Synonym Protein Names: | Karyopherin-13; Kap13; Ran-binding protein 13; RanBP13 |
| Protein Family: | Importin |
| UniProt Gene Name: | IPO13 |
| UniProt Entry Name: | IPO13_HUMAN |
 | Western blot analysis of extracts of HeLa cells, using IPO13 antibody (CAB16472) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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