Anti-Integrin linked ILK Antibody (CAB4571)

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SKU:
CAB4571
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HEL-S-28
ILK-1
ILK-2
P59
p59ILK
Frequently bought together:

Description

Product Name:Integrin linked ILK Rabbit mAb
Product Code:CAB4571
Size:20uL, 50uL, 100uL
Synonyms:HEL-S-28, ILK-1, ILK-2, P59, p59ILK
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Integrin linked ILK
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, Raji, Mouse spleen, Mouse kidney, Rat lung, Rat spleen, Rat kidney
Immunogen:A synthesized peptide derived from human Integrin linked ILK
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3611
Uniprot:Q13418
Calculated MW:51kDa
Observed MW:49KDa
UniProt Protein Function:ILK: a tyrosine kinase-like kinase of the MLK family. Couples integrins and growth factors to downstream pathways involved in cell survival, cell cycle control, cell-cell adhesion and cell motility. Functions as a scaffold bridging the extra-cellular matrix and growth factor receptors to the actin cytoskeleton through interactions with the ILK-PINCH complex. This complex, which includes integrin, PINCH (which links ILK to receptor tyrosine kinases via Nck2), PARVA and affixin, is considered to be one of the convergence points of integrin- and growth factor-signaling pathways. May be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Stimulated downstream of PI3 kinase. Increased expression is correlated with progression of several tumor types, including breast, prostate, and colon carcinomas. Overexpression drives anchorage-independent growth and faster cell cycle.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, TKL; TKL group; MLK family; ILK subfamily

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: cell junction; cytoplasm; cytosol; focal adhesion; membrane; nucleoplasm

Molecular Function:protein binding; protein kinase binding; protein serine/threonine kinase activity

Biological Process: cell-matrix adhesion; integrin-mediated signaling pathway; positive regulation of phosphorylation; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation

NCBI Summary:This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
UniProt Code:Q13418
NCBI GenInfo Identifier:9973397
NCBI Gene ID:3611
NCBI Accession:Q13418.2
UniProt Secondary Accession:Q13418,P57043, Q68DZ3, B7Z1I0, B7Z418, D3DQU0,
UniProt Related Accession:Q13418
Molecular Weight:36,467 Da
NCBI Full Name:Integrin-linked protein kinase
NCBI Synonym Full Names:integrin linked kinase
NCBI Official Symbol:ILK  
NCBI Official Synonym Symbols:P59; ILK-1; ILK-2; p59ILK; HEL-S-28  
NCBI Protein Information:integrin-linked protein kinase
UniProt Protein Name:Integrin-linked protein kinase
UniProt Synonym Protein Names:59 kDa serine/threonine-protein kinase; ILK-1; ILK-2; p59ILK
Protein Family:Integrin-linked protein kinase
UniProt Gene Name:ILK  
UniProt Entry Name:ILK_HUMAN

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