| UniProt Protein Function: | INPP5K: Inositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5- trisphosphate. May negatively regulate assembly of the actin cytoskeleton. Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - inositol phosphate; Phosphatase (non-protein); EC 3.1.3.56 Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: ruffle; neuron projection; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; plasma membrane; trans-Golgi network; cytosol; nucleus Molecular Function:protein binding; inositol trisphosphate phosphatase activity; inositol-polyphosphate 5-phosphatase activity; lipid phosphatase activity; inositol bisphosphate phosphatase activity; vasopressin receptor activity Biological Process: negative regulation of MAP kinase activity; positive regulation of transcription, DNA-dependent; regulation of glycogen biosynthetic process; negative regulation of peptidyl-serine phosphorylation; negative regulation of insulin receptor signaling pathway; glucose homeostasis; negative regulation of protein amino acid phosphorylation; phospholipid metabolic process; negative regulation of dephosphorylation; negative regulation of glycogen biosynthetic process; negative regulation of retroviral genome replication; negative regulation of calcium ion transport; negative regulation of stress fiber formation; negative regulation of protein kinase B signaling cascade; in utero embryonic development; cellular response to hormone stimulus; G-protein coupled receptor protein signaling pathway; dephosphorylation; cellular response to insulin stimulus; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; negative regulation of protein kinase activity; phosphoinositide dephosphorylation; actin cytoskeleton organization and biogenesis; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q9BT40 |
| NCBI GenInfo Identifier: | 116242791 |
| NCBI Gene ID: | 51763 |
| NCBI Accession: | Q9BT40.3 |
| UniProt Secondary Accession: | Q9BT40,Q15733, Q9NPJ5, Q9P2R5, B2R6I2, B2R750, D3DTH8 |
| UniProt Related Accession: | Q9BT40 |
| Molecular Weight: | 42,784 Da |
| NCBI Full Name: | Inositol polyphosphate 5-phosphatase K |
| NCBI Synonym Full Names: | inositol polyphosphate-5-phosphatase K |
| NCBI Official Symbol: | INPP5K |
| NCBI Official Synonym Symbols: | PPS; SKIP |
| NCBI Protein Information: | inositol polyphosphate 5-phosphatase K; skeletal muscle and kidney-enriched inositol phosphatase |
| UniProt Protein Name: | Inositol polyphosphate 5-phosphatase K |
| UniProt Synonym Protein Names: | Skeletal muscle and kidney-enriched inositol phosphatase |
| Protein Family: | Inositol polyphosphate 5-phosphatase |
| UniProt Gene Name: | INPP5K |
| UniProt Entry Name: | INP5K_HUMAN |
