Anti-INPP4B Antibody (CAB16461)
- SKU:
- CAB16461
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-INPP4B Antibody |
| Antibody SKU: | CAB16461 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-600 of human INPP4B (NP_003857.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, A375 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-600 of human INPP4B (NP_003857.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GLRK LLHR FETE RRNT GYQF IYYS PENT AKAK EVLS NINQ LQPL IATH ADLL LNSA SQHS PDSL KNSL KMLS EKTE LFVH AFKD QLVR SALL ALYT ARPG GILK KPPS PKSS TEES SPQD QPPV MRGQ DSIP HHSD YDEE EWDR VWAN VGKS LNCI IAMV DKLI ERDG GSEG SGGN NDGE KEPS LTDA IPSH PRED WYEQ LYPL ILTL KDCM GEVV NRAK Q |
| Gene ID: | 8821 |
| Uniprot: | O15327 |
| Cellular Location: | |
| Calculated MW: | 14kDa/104kDa |
| Observed MW: | 98kDa |
| Synonyms: | INPP4B |
| Background: | INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3, 4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. |
| UniProt Protein Function: | INPP4B: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate. Widely expressed with highest levels occurring in the skeletal muscle and heart. Strongly inhibited by inositol hexakisphosphate. Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.66; Phosphatase, lipid Chromosomal Location of Human Ortholog: 4q31.21 Cellular Component: cytoplasm; cytosol Molecular Function:inositol-1,3,4-trisphosphate 4-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; protein binding Biological Process: inositol phosphate metabolic process; phosphatidylinositol biosynthetic process; signal transduction |
| NCBI Summary: | INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15327 |
| NCBI GenInfo Identifier: | 218512158 |
| NCBI Gene ID: | 8821 |
| NCBI Accession: | O15327.4 |
| UniProt Secondary Accession: | O15327,Q2TAI2, Q5XLE7, Q6IN59, Q6PJB4, |
| UniProt Related Accession: | O15327 |
| Molecular Weight: | 14,740 Da |
| NCBI Full Name: | Type II inositol 3,4-bisphosphate 4-phosphatase |
| NCBI Synonym Full Names: | inositol polyphosphate-4-phosphatase type II B |
| NCBI Official Symbol: | INPP4B |
| NCBI Protein Information: | type II inositol 3,4-bisphosphate 4-phosphatase |
| UniProt Protein Name: | Type II inositol 3,4-bisphosphate 4-phosphatase |
| UniProt Synonym Protein Names: | Inositol polyphosphate 4-phosphatase type II |
| Protein Family: | Type II inositol 3,4-bisphosphate 4-phosphatase |
| UniProt Gene Name: | INPP4B |
| UniProt Entry Name: | INP4B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using INPP4B antibody (CAB16461) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 150s. |
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