Anti-ING4 Antibody (CAB5833)
- SKU:
- CAB5833
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-ING4 Antibody |
| Antibody SKU: | CAB5833 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human ING4 (NP_001121054.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, 293T, Raji, A-549, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human ING4 (NP_001121054.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAG MYLE HYLD SIEN LPFE LQRN FQLM RDLD QRTE DLKA EIDK LATE YMSS ARSL SSEE KLAL LKQI QEAY GKCK EFGD DKVQ LAMQ TYEM VDKH IRRL DTDL ARFE ADLK EKQI ESSD YDSS SSKG KKKG RTQK EKKA ARAR SKGK NSDE EAPK TAQK KLKL VRTS PEYG MPSV TFGS VHPS DVLD MP |
| Gene ID: | 51147 |
| Uniprot: | Q9UNL4 |
| Cellular Location: | Nucleus |
| Calculated MW: | 20kDa/25kDa/28kDa |
| Observed MW: | 29kDa |
| Synonyms: | ING4, my036, p29ING4 |
| Background: | This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. |
| UniProt Protein Function: | ING4: similar to ING1, a tumor suppressor protein that can interact with p53, inhibit cell growth, and induce apoptosis. Contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind p53 and p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined. |
| UniProt Protein Details: | Protein type:Tumor suppressor; Transcription factor Chromosomal Location of Human Ortholog: 12p13.31 Cellular Component: histone acetyltransferase complex; nucleoplasm; nucleus Molecular Function:methylated histone residue binding; protein binding; transcription coactivator activity Biological Process: apoptosis; cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA replication; negative regulation of cell proliferation; negative regulation of growth; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; protein amino acid acetylation |
| NCBI Summary: | This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UNL4 |
| NCBI GenInfo Identifier: | 57012981 |
| NCBI Gene ID: | 51147 |
| NCBI Accession: | Q9UNL4.1 |
| UniProt Secondary Accession: | Q9UNL4,Q0EF62, Q0EF63, Q4VBQ6, Q96E15, Q9H3J0, A4KYM4 A4KYM6, D3DUR8, |
| UniProt Related Accession: | Q9UNL4 |
| Molecular Weight: | 20,482 Da |
| NCBI Full Name: | Inhibitor of growth protein 4 |
| NCBI Synonym Full Names: | inhibitor of growth family member 4 |
| NCBI Official Symbol: | ING4 |
| NCBI Official Synonym Symbols: | my036; p29ING4 |
| NCBI Protein Information: | inhibitor of growth protein 4 |
| UniProt Protein Name: | Inhibitor of growth protein 4 |
| UniProt Synonym Protein Names: | p29ING4 |
| Protein Family: | Inhibitor of growth protein |
| UniProt Gene Name: | ING4 |
| UniProt Entry Name: | ING4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ING4 antibody (CAB5833) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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