Anti-IMPG1 Antibody (CAB16387)

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SKU:
CAB16387
Product type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-IMPG1 Antibody
Antibody SKU:CAB16387
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-300 of human IMPG1 (NP_001554.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:Rat
Positive Samples:Rat eye
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-300 of human IMPG1 (NP_001554.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TKDI SINI YHSE TKDI DNPP RNET TEST EKMY KMST MRRI FDLA KHRT KRSA FFPT GVKV CPQE SMKQ ILDS LQAY YRLR VCQE AVWE AYRI FLDR IPDT GEYQ DWVS ICQQ ETFC LFDI GKNF SNSQ EHLD LLQQ RIKQ RSFP DRKD EISA EKTL GEPG ETIV ISTD VANV SLGP FPLT PDDT LLNE ILDN TLND TKMP TTER ETEF AVLE EQRV ELSV SLVN QKFK AELA DSQS PYYQ ELAG KSQL QMQK IFKK LPGF KKIH VLGF RPKK EKDG SSST
Gene ID:3617
Uniprot:Q17R60
Cellular Location:Secreted
Calculated MW:17kDa/89kDa
Observed MW:80kDa
Synonyms:IMPG1, GP147, IPM150, SPACR, VMD4
Background:This gene encodes a protein that is a major component of the retinal interphotoreceptor matrix. The encoded protein is a proteoglycan that is thought to play a role in maintaining viability of photoreceptor cells and in adhesion of the neural retina to the retinal pigment epithelium. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:IMPG1: May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6q14.2-q15

Cellular Component: proteinaceous extracellular matrix

Molecular Function:extracellular matrix structural constituent

Biological Process: visual perception

Disease: Macular Dystrophy, Vitelliform, 4

NCBI Summary:This gene encodes a protein that is a major component of the retinal interphotoreceptor matrix. The encoded protein is a proteoglycan that is thought to play a role in maintaining viability of photoreceptor cells and in adhesion of the neural retina to the retinal pigment epithelium. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Code:Q17R60
NCBI GenInfo Identifier:538917173
NCBI Gene ID:3617
NCBI Accession:NP_001269297.1
UniProt Secondary Accession:Q17R60,O43686, O95094, Q9BWZ1, A6NNZ6,
UniProt Related Accession:Q17R60
Molecular Weight:89,387 Da
NCBI Full Name:interphotoreceptor matrix proteoglycan 1 isoform 2
NCBI Synonym Full Names:interphotoreceptor matrix proteoglycan 1
NCBI Official Symbol:IMPG1  
NCBI Official Synonym Symbols:GP147; SPACR; IPM150  
NCBI Protein Information:interphotoreceptor matrix proteoglycan 1; sialoprotein associated with cones and rods; interphotoreceptor matrix proteoglycan of 150 kDa
UniProt Protein Name:Interphotoreceptor matrix proteoglycan 1
UniProt Synonym Protein Names:Interphotoreceptor matrix proteoglycan of 150 kDa; IPM-150; Sialoprotein associated with cones and rods
Protein Family:Interphotoreceptor matrix proteoglycan
UniProt Gene Name:IMPG1  
UniProt Entry Name:IMPG1_HUMAN
Anti-IMPG1 Antibody (CAB16387)Western blot analysis of extracts of rat eye, using IMPG1 antibody (CAB16387) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

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