Anti-IMP2 Antibody (CAB5189)
- SKU:
- CAB5189
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-IMP2 Antibody |
| Antibody SKU: | CAB5189 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human IMP2 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | HT-29, 293T, HepG2 |
| Immunogen: | A synthesized peptide derived from human IMP2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10644 |
| Uniprot: | Q9Y6M1 |
| Cellular Location: | |
| Calculated MW: | 66, 62kDa |
| Observed MW: | 65KDa/70KDa |
| Synonyms: | IMP-2, IMP2, VICKZ2 |
| Background: | This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016] |
| UniProt Protein Function: | IGF2BP2: Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May regulate translation of target mRNAs. Belongs to the RRM IMP/VICKZ family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; Translation Chromosomal Location of Human Ortholog: 3q27.2 Cellular Component: cytoskeleton; cytoplasm; nucleus; cytosol Molecular Function:protein binding; mRNA 3'-UTR binding; nucleotide binding; translation regulator activity; mRNA 5'-UTR binding Biological Process: anatomical structure morphogenesis; mRNA transport; negative regulation of translation; gene expression; regulation of cytokine biosynthetic process Disease: Diabetes Mellitus, Noninsulin-dependent |
| NCBI Summary: | This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. [provided by RefSeq, May 2014] |
| UniProt Code: | Q9Y6M1 |
| NCBI GenInfo Identifier: | 224471831 |
| NCBI Gene ID: | 10644 |
| NCBI Accession: | Q9Y6M1.2 |
| UniProt Secondary Accession: | Q9Y6M1,A0A4Z0, B3FTN2, B3FTN3, B3FTN4, |
| UniProt Related Accession: | Q9Y6M1 |
| Molecular Weight: | 599 |
| NCBI Full Name: | Insulin-like growth factor 2 mRNA-binding protein 2 |
| NCBI Synonym Full Names: | insulin-like growth factor 2 mRNA binding protein 2 |
| NCBI Official Symbol: | IGF2BP2 |
| NCBI Official Synonym Symbols: | IMP2; IMP-2; VICKZ2 |
| NCBI Protein Information: | insulin-like growth factor 2 mRNA-binding protein 2; VICKZ family member 2; IGF2 mRNA-binding protein 2; IGF-II mRNA-binding protein 2 |
| UniProt Protein Name: | Insulin-like growth factor 2 mRNA-binding protein 2 |
| UniProt Synonym Protein Names: | Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; VICKZ family member 2 |
| Protein Family: | Insulin-like growth factor 2 mRNA-binding protein |
| UniProt Gene Name: | IGF2BP2 |
| UniProt Entry Name: | IF2B2_HUMAN |
 | Western blot - IMP2 Rabbit mAb (CAB5189) |
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