Anti-IL-3 Antibody (CAB5671)
- SKU:
- CAB5671
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | IL3 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB5671 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-152 of human IL3 (NP_000579.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse liver, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-152 of human IL3 (NP_000579.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | APMT QTTP LKTS WVNC SNMI DEII THLK QPPL PLLD FNNL NGED QDIL MENN LRRP NLEA FNRA VKSL QNAS AIES ILKN LLPC LPLA TAAP TRHP IHIK DGDW NEFR RKLT FYLK TLEN AQAQ QTTL SLAI F |
| Gene ID: | 3562 |
| Uniprot: | P08700 |
| Cellular Location: | Secreted |
| Calculated MW: | 17kDa |
| Observed MW: | 22kDa |
| Synonyms: | IL3, IL-3, MCGF, MULTI-CSF |
| Background: | The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. |
| UniProt Protein Function: | IL3: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Secreted, signal peptide; Secreted; Cytokine; Oncoprotein; Apoptosis Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: extracellular space; extracellular region Molecular Function:interleukin-3 receptor binding; growth factor activity; cytokine activity Biological Process: nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell signaling; positive regulation of tyrosine phosphorylation of Stat5 protein; embryonic hemopoiesis; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; immune response; positive regulation of myeloid leukocyte differentiation; positive regulation of DNA replication |
| NCBI Summary: | The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08700 |
| NCBI GenInfo Identifier: | 124330 |
| NCBI Gene ID: | 3562 |
| NCBI Accession: | P08700.2 |
| UniProt Secondary Accession: | P08700,Q6GS87, |
| UniProt Related Accession: | P08700 |
| Molecular Weight: | 17,233 Da |
| NCBI Full Name: | Interleukin-3 |
| NCBI Synonym Full Names: | interleukin 3 |
| NCBI Official Symbol: | IL3 |
| NCBI Official Synonym Symbols: | IL-3; MCGF; MULTI-CSF |
| NCBI Protein Information: | interleukin-3; mast cell growth factor; mast-cell growth factor; P-cell stimulating factor; P-cell-stimulating factor; hematopoietic growth factor; colony-stimulating factor, multiple; multilineage-colony-stimulating factor; multipotential colony-stimulating factor |
| UniProt Protein Name: | Interleukin-3 |
| UniProt Synonym Protein Names: | Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL3 |
| UniProt Entry Name: | IL3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL3 antibody (CAB5671) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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