Anti-IL-21R Antibody (CAB7468)

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SKU:
CAB7468
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:IL21R Rabbit Polyclonal Antibody
Antibody SKU:CAB7468
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-240 of human IL21R (NP_851565.4).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-87MG, Mouse spleen, Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-240 of human IL21R (NP_851565.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GVSM PRGW AAPL LLLL LQGG WGCP DLVC YTDY LQTV ICIL EMWN LHPS TLTL TWQD QYEE LKDE ATSC SLHR SAHN ATHA TYTC HMDV FHFM ADDI FSVN ITDQ SGNY SQEC GSFL LAES IKPA PPFN VTVT FSGQ YNIS WRSD YEDP AFYM LKGK LQYE LQYR NRGD PWAV SPRR KLIS VDSR SVSL LPLE FRKD SSYE LQVR AGPM PGSS YQGT WSEW S
Gene ID:50615
Uniprot:Q9HBE5
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:59kDa
Observed MW:70kDa
Synonyms:IL21R, CD360, NILR
Background:The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
UniProt Protein Function:IL21R: This is a receptor for interleukin-21
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 16p11

Cellular Component: integral to membrane

Molecular Function:interleukin-21 receptor activity

Biological Process: natural killer cell activation

Disease: Ige Responsiveness, Atopic; Il21r Immunodeficiency

NCBI Summary:The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
UniProt Code:Q9HBE5
NCBI GenInfo Identifier:20454997
NCBI Gene ID:50615
NCBI Accession:Q9HBE5.1
UniProt Secondary Accession:Q9HBE5,Q96HZ1, Q9HB91, A8K9E8, D3DWF7,
UniProt Related Accession:Q9HBE5
Molecular Weight:538
NCBI Full Name:Interleukin-21 receptor
NCBI Synonym Full Names:interleukin 21 receptor
NCBI Official Symbol:IL21R  
NCBI Official Synonym Symbols:NILR; CD360  
NCBI Protein Information:interleukin-21 receptor; IL-21 receptor; novel interleukin receptor
UniProt Protein Name:Interleukin-21 receptor
UniProt Synonym Protein Names:Novel interleukin receptor; CD_antigen: CD360
Protein Family:Interleukin-21 receptor
UniProt Gene Name:IL21R  
UniProt Entry Name:IL21R_HUMAN
Anti-IL-21R Antibody (CAB7468)Western blot analysis of extracts of various cell lines, using IL21R antibody (CAB7468) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

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