Anti-IL-17RB Antibody (CAB10147)
- SKU:
- CAB10147
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | IL17RB Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB10147 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-292 of human IL17RB (NP_061195.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:4000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, 293T, SW620, A-549, B-cell, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-292 of human IL17RB (NP_061195.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | REPT VQCG SETG PSPE WMLQ HDLI PGDL RDLR VEPV TTSV ATGD YSIL MNVS WVLR ADAS IRLL KATK ICVT GKSN FQSY SCVR CNYT EAFQ TQTR PSGG KWTF SYIG FPVE LNTV YFIG AHNI PNAN MNED GPSM SVNF TSPG CLDH IMKY KKKC VKAG SLWD PNIT ACKK NEET VEVN FTTT PLGN RYMA LIQH STII GFSQ VFEP HQKK QTRA SVVI PVTG DSEG ATVQ LTPY FPTC GSDC IRHK GTVV LCPQ TGVP FPLD NNKS KPGG WLP |
| Gene ID: | 55540 |
| Uniprot: | Q9NRM6 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 31kDa/55kDa |
| Observed MW: | 75kDa |
| Synonyms: | IL17RB, CRL4, EVI27, IL17BR, IL17RH1 |
| Background: | The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. |
| UniProt Protein Function: | IL17RB: Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:interleukin-17 receptor activity Biological Process: defense response |
| NCBI Summary: | The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NRM6 |
| NCBI GenInfo Identifier: | 21263748 |
| NCBI Gene ID: | 55540 |
| NCBI Accession: | Q9NRM6.2 |
| UniProt Secondary Accession: | Q9NRM6,Q9BPZ0, Q9NRL4, Q9NRM5, |
| UniProt Related Accession: | Q9NRM6 |
| Molecular Weight: | 31,773 Da |
| NCBI Full Name: | Interleukin-17 receptor B |
| NCBI Synonym Full Names: | interleukin 17 receptor B |
| NCBI Official Symbol: | IL17RB |
| NCBI Official Synonym Symbols: | CRL4; EVI27; IL17BR; IL17RH1 |
| NCBI Protein Information: | interleukin-17 receptor B |
| UniProt Protein Name: | Interleukin-17 receptor B |
| UniProt Synonym Protein Names: | Cytokine receptor-like 4; IL-17 receptor homolog 1; IL-17Rh1; IL17Rh1; Interleukin-17B receptor; IL-17B receptor |
| Protein Family: | Interleukin-17 receptor |
| UniProt Gene Name: | IL17RB |
| UniProt Entry Name: | I17RB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL17RB antibody (CAB10147) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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