Anti-IL-17A Antibody (CAB0688)
- SKU:
- CAB0688
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | IL17A Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB0688 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-155 of human IL17A (NP_002181.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | THP-1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-155 of human IL17A (NP_002181.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GITI PRNP GCPN SEDK NFPR TVMV NLNI HNRN TNTN PKRS SDYY NRST SPWN LHRN EDPE RYPS VIWE AKCR HLGC INAD GNVD YHMN SVPI QQEI LVLR REPP HCPN SFRL EKIL VSVG CTCV TPIV HHVA |
| Gene ID: | 3605 |
| Uniprot: | Q16552 |
| Cellular Location: | Secreted |
| Calculated MW: | 17kDa |
| Observed MW: | 17kDa |
| Synonyms: | IL17A, CTLA-8, CTLA8, IL-17, IL-17A, IL17 |
| Background: | The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. |
| UniProt Protein Function: | IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 6p12 Cellular Component: extracellular space; external side of plasma membrane Molecular Function:cytokine activity Biological Process: cell death; cell-cell signaling; apoptosis; positive regulation of interleukin-23 production; positive regulation of osteoclast differentiation; protein amino acid glycosylation; positive regulation of transcription from RNA polymerase II promoter; immune response; inflammatory response |
| NCBI Summary: | The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16552 |
| NCBI GenInfo Identifier: | 2498481 |
| NCBI Gene ID: | 3605 |
| NCBI Accession: | Q16552.1 |
| UniProt Secondary Accession: | Q16552,Q5T2P0, |
| UniProt Related Accession: | Q16552 |
| Molecular Weight: | 17,504 Da |
| NCBI Full Name: | Interleukin-17A |
| NCBI Synonym Full Names: | interleukin 17A |
| NCBI Official Symbol: | IL17A |
| NCBI Official Synonym Symbols: | IL17; CTLA8; IL-17; IL-17A |
| NCBI Protein Information: | interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) |
| UniProt Protein Name: | Interleukin-17A |
| UniProt Synonym Protein Names: | Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL17A |
| UniProt Entry Name: | IL17_HUMAN |
 | Western blot analysis of extracts of THP-1 cells, using IL17A antibody (CAB0688) at 1:1000 dilution.THP-1 cells were treated by PMA (80 nM) at 37°C for overnight. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s. |
 | Immunofluorescence analysis of L929 cells using IL17A Rabbit pAb (CAB0688) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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