Anti-IL-13 항체 (CAB2089)

Antibody Name:	IL13 Rabbit Polyclonal Antibody
Antibody SKU:	CAB2089
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 25-146 of human IL13 (NP_002179.2).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:	Mouse pancreas

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 25-146 of human IL13 (NP_002179.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	LTCL GGFA SPGP VPPS TALR ELIE ELVN ITQN QKAP LCNG SMVW SINL TAGM YCAA LESL INVS GCSA IEKT QRML SGFC PHKV SAGQ FSSL HVRD TKIE VAQF VKDL LLHL KKLF REGQ FN
Gene ID:	3596
Uniprot:	P35225
Cellular Location:	Secreted
Calculated MW:	15kDa
Observed MW:	16kDa

Synonyms:

IL13, IL-13, P600

Background:

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.

UniProt Protein Function:	IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family.
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 5q31 Cellular Component: extracellular region; extracellular space Molecular Function:interleukin-13 receptor binding; protein binding Biological Process: cell motility; cell-cell signaling; positive regulation of B cell proliferation; positive regulation of immunoglobulin production; positive regulation of macrophage activation; positive regulation of mast cell degranulation Disease: Allergic Rhinitis; Asthma, Susceptibility To
NCBI Summary:	This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
UniProt Code:	P35225
NCBI GenInfo Identifier:	239938644
NCBI Gene ID:	3596
NCBI Accession:	P35225.2
UniProt Secondary Accession:	P35225,O43644, Q4VB52, Q9UDC7,
UniProt Related Accession:	P35225
Molecular Weight:	15,816 Da
NCBI Full Name:	Interleukin-13
NCBI Synonym Full Names:	interleukin 13
NCBI Official Symbol:	IL13
NCBI Official Synonym Symbols:	P600; IL-13
NCBI Protein Information:	interleukin-13
UniProt Protein Name:	Interleukin-13
Protein Family:	Interleukin
UniProt Gene Name:	IL13
UniProt Entry Name:	IL13_HUMAN

	Western blot analysis of extracts of mouse pancreas, using IL13 antibody (CAB2089) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 2min.
	Immunohistochemistry of paraffin-embedded mouse brain using IL13 antibody (CAB2089) (40x lens).
	Immunohistochemistry of paraffin-embedded rat brain using IL13 antibody (CAB2089) (40x lens).
	Immunohistochemistry of paraffin-embedded human stomach using IL13 antibody (CAB2089) (40x lens).

Antibodies	ELISA Kits
Anti-IL-13 Antibody (CAB12453)	Human IL-13 ELISA Kit
Anti-IL-13 Antibody (CAB12460)	Human IL-13 CLIA Kit (HUES00100)
Anti-IL-13 Antibody (CAB1367)	Human IL-13 ELISA Kit (HUES01390)
	Human IL-13 ELISA Kit (HUEB0020)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)