Anti-IL-12RB2 Antibody (CAB10348)
- SKU:
- CAB10348
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | IL12RB2 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB10348 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-620 of human IL12RB2 (NP_001550.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-620 of human IL12RB2 (NP_001550.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GLLA PRQV SANS EGMD NILV TWQP PRKD PSAV QEYV VEWR ELHP GGDT QVPL NWLR SRPY NVSA LISE NIKS YICY EIRV YALS GDQG GCSS ILGN SKHK APLS GPHI NAIT EEKG SILI SWNS IPVQ EQMG CLLH YRIY WKER DSNS QPQL CEIP YRVS QNSH PINS LQPR VTYV LWMT ALTA AGES SHGN EREF CLQG K |
| Gene ID: | 3595 |
| Uniprot: | Q99665 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 74kDa/87kDa/97kDa |
| Observed MW: | 110kDa |
| Synonyms: | IL12RB2 |
| Background: | The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. |
| UniProt Protein Function: | IL12RB2: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. Belongs to the type I cytokine receptor family. Type 2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, cytokine; Membrane protein, integral; Cell cycle regulation Chromosomal Location of Human Ortholog: 1p31.3-p31.2 Cellular Component: integral to plasma membrane; external side of plasma membrane Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein kinase binding Biological Process: positive regulation of interferon-gamma production; peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; interferon-gamma production; response to lipopolysaccharide |
| NCBI Summary: | The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | Q99665 |
| NCBI GenInfo Identifier: | 12229836 |
| NCBI Gene ID: | 3595 |
| NCBI Accession: | Q99665.1 |
| UniProt Secondary Accession: | Q99665,Q2M3V3, B1AN98, B7ZKL9, F5H7L6, |
| UniProt Related Accession: | Q99665 |
| Molecular Weight: | 87,484 Da |
| NCBI Full Name: | Interleukin-12 receptor subunit beta-2 |
| NCBI Synonym Full Names: | interleukin 12 receptor, beta 2 |
| NCBI Official Symbol: | IL12RB2 |
| NCBI Protein Information: | interleukin-12 receptor subunit beta-2; IL-12R subunit beta-2; IL-12 receptor subunit beta-2; interleukin-12 receptor beta-2 chain |
| UniProt Protein Name: | Interleukin-12 receptor subunit beta-2 |
| Protein Family: | Interleukin-12 receptor |
| UniProt Gene Name: | IL12RB2 |
| UniProt Entry Name: | I12R2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL12RB2 antibody (CAB10348) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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