Anti-IL-11RA 항체 (CAB6627)

Antibody Name:	IL11RA Rabbit Polyclonal Antibody
Antibody SKU:	CAB6627
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human IL11RA (NP_001136256.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	Mouse kidney, Mouse heart, Mouse skeletal muscle, Rat liver

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human IL11RA (NP_001136256.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	WGPP GVQY GQPG RSVK LCCP GVTA GDPV SWFR DGEP KLLQ GPDS GLGH ELVL AQAD STDE GTYI CQTL DGAL GGTV TLQL GYPP ARPV VSCQ AADY ENFS CTWS PSQI SGLP TRYL TSYR KKTV LGAD SQRR SPST GPWP CPQD PLGA ARCV VHGA EFWS QYRI NVTE VNPL GAST RLLD VSLQ SILR PDPP QGLR VESV PGYP RRLR ASWT YPAS WPCQ PHFL LKFR LQYR PAQH PAWS TVEP AGLE EVIT DAVA GLPH A
Gene ID:	3590
Uniprot:	Q14626
Cellular Location:	Membrane, Single-pass type I membrane protein
Calculated MW:	41kDa/45kDa
Observed MW:	45kDa

Synonyms:

IL11RA, CRSDA

Background:

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene.

UniProt Protein Function:	IL11RA: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Defects in IL11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 9p13 Cellular Component: integral to plasma membrane Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; signal transducer activity; transmembrane receptor activity Biological Process: cytokine and chemokine mediated signaling pathway; signal transduction; developmental process; embryo implantation Disease: Craniosynostosis And Dental Anomalies
NCBI Summary:	Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
UniProt Code:	Q14626
NCBI GenInfo Identifier:	55976300
NCBI Gene ID:	3590
NCBI Accession:	Q14626.2
UniProt Secondary Accession:	Q14626,Q16542, Q5VZ80, Q7KYJ7,
UniProt Related Accession:	Q14626
Molecular Weight:	422
NCBI Full Name:	Interleukin-11 receptor subunit alpha
NCBI Synonym Full Names:	interleukin 11 receptor, alpha
NCBI Official Symbol:	IL11RA
NCBI Official Synonym Symbols:	CRSDA
NCBI Protein Information:	interleukin-11 receptor subunit alpha; IL-11R subunit alpha; IL-11 receptor subunit alpha; interleukin-11 receptor alpha chain
UniProt Protein Name:	Interleukin-11 receptor subunit alpha
Protein Family:	Interleukin-11 receptor
UniProt Gene Name:	IL11RA
UniProt Entry Name:	I11RA_HUMAN

Western blot analysis of extracts of various cell lines, using IL11RA Antibody (CAB6627) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

Antibodies

IL11RA Antibody (PACO00956)

IL11RA Antibody (PACO09910)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)